Serper M R, Davidson M, Harvey P D
Department of Psychiatry, New York University Medical School, NY 10016.
Schizophr Res. 1994 Aug;13(1):65-71. doi: 10.1016/0920-9964(94)90061-2.
Improvement in auditory selective attention performance was examined in acute schizophrenic inpatients (n = 13) both off and on medication using the digit span distraction task. Subjects were tested at drug-free baseline and weekly for three weeks during treatment with haloperidol. Improvements in distractability preceded and predicted clinical improvements. A control group of stable schizophrenic outpatients (n = 12) medicated at all testing intervals were examined during the same time period. No significant clinical or attentional changes were found in the control group over the four testing intervals. These results suggest that specific types of attentional functions are intrinsically related to the biological processes affected by neuroleptic treatment and lend preliminary support to the contention that schizophrenic symptoms are mediated by attentional impairment.
使用数字广度分心任务，对13名急性精神分裂症住院患者在停药和服药状态下的听觉选择性注意力表现改善情况进行了检查。受试者在无药物基线状态下接受测试，并在使用氟哌啶醇治疗的三周内每周进行测试。注意力分散性的改善先于并预示着临床改善。在同一时期，对一组12名在所有测试间隔都接受药物治疗的稳定精神分裂症门诊患者作为对照组进行了检查。在四个测试间隔期间，对照组未发现明显的临床或注意力变化。这些结果表明，特定类型的注意力功能与受抗精神病药物治疗影响的生物学过程存在内在联系，并为精神分裂症症状由注意力损害介导的观点提供了初步支持。
