Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Department of Respiratory Medicine, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.
Clin Chest Med. 2014 Jun;35(2):283-93. doi: 10.1016/j.ccm.2014.02.009. Epub 2014 Apr 12.
The systemic effects and comorbidities of chronic respiratory disease such as COPD contribute substantially to its burden. Symptoms in COPD do not solely arise from the degree of airflow obstruction as exercise limitation is compounded by the specific secondary manifestations of the disease including skeletal muscle impairment, osteoporosis, mood disturbance, anemia, and hormonal imbalance. Pulmonary rehabilitation targets the systemic manifestations of COPD, the causes of which include inactivity, systemic inflammation, hypoxia and corticosteroid treatment. Comorbidities are common, including cardiac disease, obesity, and metabolic syndrome and should not preclude pulmonary rehabilitation as they may also benefit from similar approaches.
慢性呼吸疾病（如 COPD）的全身性影响和合并症对其负担有很大贡献。COPD 的症状不仅源于气流阻塞的程度，还受到疾病的特定继发性表现的影响，包括骨骼肌损伤、骨质疏松症、情绪障碍、贫血和激素失衡。肺康复针对 COPD 的全身性表现，其病因包括不活动、全身炎症、缺氧和皮质类固醇治疗。合并症很常见，包括心脏病、肥胖症和代谢综合征，不应该排除肺康复，因为它们也可能受益于类似的方法。
