Drut R, Drut R M
Medicina (B Aires). 1989;49(6):603-6.
The first case was a 2 year-old girl with Blackfan-Diamond anemia who developed the immune reaction two weeks after receiving two transfusions of sedimented erythrocytes. HLA typing of lymphocytes showed the presence of three HLA-A, two of which were present in the donors. The second was a newborn who initially received an exchange transfusion and three weeks later another transfusion of whole blood. Both cases exhibited a severe bone marrow involvement and a skin biopsy with the pattern of keratinocyte apoptosis and lymphocyte satellitosis. These histological findings although highly suggestive must be evaluated in the appropriate clinical setting.
第一例是一名患有黑范-戴蒙德贫血的2岁女孩，在接受两次沉淀红细胞输血两周后出现免疫反应。淋巴细胞的HLA分型显示存在三种HLA-A，其中两种存在于供体中。第二例是一名新生儿，最初接受了换血输血，三周后又接受了一次全血输血。两例均表现出严重的骨髓受累，皮肤活检显示有角质形成细胞凋亡和淋巴细胞卫星现象。这些组织学发现虽然极具提示性，但必须在适当的临床背景下进行评估。
