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眼下细纹:一项关于线性基底细胞癌的大型前瞻性病例系列研究。

Lines under the eyes: a large prospective case series of linear basal cell carcinomas.

作者信息

Rutkowski D, Collier N J, Telfer N, Ghura V

机构信息

Mohs Unit, Department of Dermatology, Salford Royal Hospital NHS Foundation Trust, Northern Care Alliance NHS Group, Salford, England.

Dermatology Research Centre, NIHR Biomedical Research Centre, University of Manchester, Manchester, UK.

出版信息

Arch Dermatol Res. 2023 Apr;315(3):621-624. doi: 10.1007/s00403-022-02385-5. Epub 2022 Aug 12.

DOI:10.1007/s00403-022-02385-5
PMID:35962197
Abstract

Basal cell carcinomas (BCC) are the most common form of cancer globally. Linear BCCs are an unusual variant which are generally defined by having a length three times longer than the width and exhibiting relatively straight edges. In this report, we describe the largest global cohort (n = 31) with this rare subtype. Within this cohort, 22 were in the periocular region, 27 underwent Mohs micrographic surgery and 12 involved oculoplastic reconstruction. These results suggest that, whilst this subtype is relatively rare, it may be more prevalent than previously thought. Dermatologists and other specialities managing skin cancer, particularly ophthalmologists, should, therefore, be aware of this subtype, as it is often more aggressive than other BCC subtypes, often requiring multi-disciplinary management.

摘要

基底细胞癌(BCC)是全球最常见的癌症形式。线状基底细胞癌是一种不寻常的变体,通常定义为长度比宽度长三倍且边缘相对笔直。在本报告中,我们描述了全球最大的这一罕见亚型队列(n = 31)。在该队列中,22例位于眼周区域,27例接受了莫氏显微外科手术,12例涉及眼整形重建。这些结果表明,虽然这种亚型相对罕见,但可能比之前认为的更为普遍。因此,皮肤科医生和其他治疗皮肤癌的专科医生,尤其是眼科医生,应该了解这种亚型,因为它通常比其他基底细胞癌亚型更具侵袭性,常常需要多学科管理。

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本文引用的文献

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Prevalence of wound complications following Mohs micrographic surgery (MMS): a cross-sectional study of 1000 patients undergoing MMS and wound repair in a UK teaching hospital.Mohs 显微外科手术后伤口并发症的发生率:英国教学医院 1000 例接受 Mohs 显微外科手术和伤口修复患者的横断面研究。
Clin Exp Dermatol. 2022 Aug;47(8):1536-1542. doi: 10.1111/ced.15226. Epub 2022 May 25.
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Recurrence of linear basal cell carcinoma.
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Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.维莫德吉治疗晚期基底细胞癌患者的长期安全性和有效性:关键ERIVANCE BCC研究的最终更新
BMC Cancer. 2017 May 16;17(1):332. doi: 10.1186/s12885-017-3286-5.
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Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.基底细胞癌优先起源于毛囊和机械感觉微环境中的干细胞。
Cell Stem Cell. 2015 Apr 2;16(4):400-12. doi: 10.1016/j.stem.2015.02.006.
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Br J Cancer. 2014 Jul 8;111(1):203-6. doi: 10.1038/bjc.2014.265. Epub 2014 May 29.
8
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Indian Dermatol Online J. 2013 Jan;4(1):12-7. doi: 10.4103/2229-5178.105456.
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Digging for gold in a dermatology clinic.
Clin Exp Dermatol. 2011 Dec;36(8):919. doi: 10.1111/j.1365-2230.2011.04115.x. Epub 2011 Aug 25.
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