Stadler P, van Amstel S R
Departement Geneeskunde, Fakulteit Veeartsenykunde, Universiteit van Pretoria, Repubilek van Suid-Afrika.
J S Afr Vet Assoc. 1989 Dec;60(4):201-5.
The results of a study conducted to determine the clinico-pathological changes in 4 experimentally-induced cases of endotoxaemia in the horse are reported on. Endotoxaemia was induced by injecting commercially available E. coli 055:B5 lipopolysaccharide intravenously at a dose of 1 microgram kg-1. The haematocrit, red cell count, total and differential white cell counts, thrombocyte count, prothrombin time, partial thromboplastin time, fibrinogen level, level of fibrin degradation products, arterial acid-base status, serum lactate and blood glucose were determined repeatedly. Changes that occurred, include increases in the haematocrit and red cell count, a leucopaenia followed by a leucocytosis caused mainly by changes in the number of neutrophils, the development of disseminated intravascular coagulation, minor changes in the arterial acid base parameters, hyperglycaemia followed by hypoglycaemia and an increase in serum lactate.
本文报告了一项针对4例实验诱导的马内毒素血症病例进行的临床病理变化研究结果。通过静脉注射剂量为1微克/千克的市售大肠杆菌055:B5脂多糖诱导内毒素血症。反复测定血细胞比容、红细胞计数、白细胞总数及分类计数、血小板计数、凝血酶原时间、部分凝血活酶时间、纤维蛋白原水平、纤维蛋白降解产物水平、动脉酸碱状态、血清乳酸和血糖。所发生的变化包括血细胞比容和红细胞计数增加、白细胞减少随后是主要由中性粒细胞数量变化引起的白细胞增多、弥散性血管内凝血的发展、动脉酸碱参数的轻微变化、高血糖随后是低血糖以及血清乳酸增加。
