Stadler P, Van Amstel S R
Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort.
Onderstepoort J Vet Res. 1989 Sep;56(3):207-9.
Commercially available Escherichia coli 055: B5 lipopolysaccharide was administered intravenously experimentally at a dosage of 10 micrograms/kg to 2 horses. Various clinical and clinico-pathological parameters were monitored before and after the endotoxin administration. Because of a hopeless prognosis, and for humane reasons, euthanasia was applied on both horses 6 h after administration. Values recorded for the different parameters, including the blood lactate level, were consistent with a lethal condition. It would appear that an intravenous dose of 10 micrograms/kg of endotoxin is potentially lethal to horses.
将市售的大肠杆菌055:B5脂多糖以10微克/千克的剂量通过静脉注射给2匹马进行实验。在内毒素给药前后监测各种临床和临床病理参数。由于预后无望，出于人道原因，在给药后6小时对两匹马实施了安乐死。记录的包括血乳酸水平在内的不同参数值与致命状况一致。静脉注射10微克/千克的内毒素剂量似乎对马有潜在的致死性。
