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Accumulation of serial forces on TCR and CD8 frequently applied by agonist antigenic peptides embedded in MHC molecules triggers calcium in T cells.TCR 和 CD8 上频繁受到 MHC 分子中嵌入的激动性抗原肽施加的串联力的积累触发 T 细胞内的钙。
J Immunol. 2014 Jul 1;193(1):68-76. doi: 10.4049/jimmunol.1303436. Epub 2014 Jun 2.
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Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement.TCR亲和力与共受体连接必要性之间的相互作用：高亲和力的肽-主要组织相容性复合体/TCR相互作用克服了CD8结合的缺乏。
J Immunol. 2003 Nov 1;171(9):4493-503. doi: 10.4049/jimmunol.171.9.4493.
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The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.二维 TCR 和 pMHC 相互作用的动力学决定了 T 细胞的反应性。
Nature. 2010 Apr 8;464(7290):932-6. doi: 10.1038/nature08944. Epub 2010 Mar 31.
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Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers.CD8在肽/主要组织相容性复合体多聚体与T细胞受体结合及激活过程中的关键作用。
J Exp Med. 2000 Jan 17;191(2):335-46. doi: 10.1084/jem.191.2.335.
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Glu227-->Lys substitution in the acidic loop of major histocompatibility complex class I alpha 3 domain distinguishes low avidity CD8 coreceptor and avidity-enhanced CD8 accessory functions.主要组织相容性复合体I类α3结构域酸性环中Glu227突变为Lys可区分低亲和力CD8共受体和亲和力增强的CD8辅助功能。
J Exp Med. 1996 Nov 1;184(5):1671-83. doi: 10.1084/jem.184.5.1671.
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Ligand density determines the efficiency of negative selection in the thymus.配体密度决定胸腺中阴性选择的效率。
Transplantation. 2001 Jul 27;72(2):305-11. doi: 10.1097/00007890-200107270-00025.
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Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells.力调节原位TCR-肽结合的II类主要组织相容性复合体动力学决定CD4+T细胞的功能。
J Immunol. 2015 Oct 15;195(8):3557-64. doi: 10.4049/jimmunol.1501407. Epub 2015 Sep 2.
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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.T细胞受体的触发严重依赖于其肽-MHC配体的尺寸。
Nature. 2005 Jul 28;436(7050):578-82. doi: 10.1038/nature03843.
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CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement.与CD4 T细胞一样，CD8 T细胞由MHC-肽配体对TCR的多价结合触发，而非单价结合。
J Immunol. 2006 Feb 1;176(3):1498-505. doi: 10.4049/jimmunol.176.3.1498.
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2D Kinetic Analysis of TCR and CD8 Coreceptor for LCMV GP33 Epitopes.针对 LCMV GP33 表位的 TCR 和 CD8 共受体的 2D 动力学分析。
Front Immunol. 2018 Oct 15;9:2348. doi: 10.3389/fimmu.2018.02348. eCollection 2018.
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Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.免疫突触：结构、分子机制及在疾病中的治疗意义
Signal Transduct Target Ther. 2025 Aug 11;10(1):254. doi: 10.1038/s41392-025-02332-6.
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Remote Force Modulation of the T-Cell Receptor Reveals an NFAT-Threshold for CD4 T-Cell Activation.T细胞受体的远程力调节揭示了CD4 T细胞激活的NFAT阈值。
Eur J Immunol. 2025 Jun;55(6):e51716. doi: 10.1002/eji.202451716.
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TCR catch bonds nonlinearly control CD8 cooperation to shape T cell specificity.TCR捕获键非线性地控制CD8协同作用以塑造T细胞特异性。
Cell Res. 2025 Apr;35(4):265-283. doi: 10.1038/s41422-025-01077-9. Epub 2025 Feb 27.
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Mechanical force regulates ligand binding and function of PD-1.机械力调节 PD-1 的配体结合和功能。
Nat Commun. 2024 Sep 27;15(1):8339. doi: 10.1038/s41467-024-52565-2.
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Mechanical control of antigen detection and discrimination by T and B cell receptors.T 和 B 细胞受体对抗原检测和识别的机械控制。
Biophys J. 2024 Aug 6;123(15):2234-2255. doi: 10.1016/j.bpj.2024.05.020. Epub 2024 May 23.
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Force-Induced Site-Specific Enzymatic Cleavage Probes Reveal That Serial Mechanical Engagement Boosts T Cell Activation.力诱导的定点酶切探针揭示，连续的机械刺激可增强 T 细胞的激活。
J Am Chem Soc. 2024 Mar 20;146(11):7233-7242. doi: 10.1021/jacs.3c08137. Epub 2024 Mar 7.
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Actin cytoskeleton remodeling at the cancer cell side of the immunological synapse: good, bad, or both?免疫突触中癌细胞侧的肌动蛋白细胞骨架重构：好、坏，还是皆有？
Front Immunol. 2023 Oct 5;14:1276602. doi: 10.3389/fimmu.2023.1276602. eCollection 2023.
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What's the Catch? The Significance of Catch Bonds in T Cell Activation.有何玄机？细胞激活中“捕获键”的意义。
J Immunol. 2023 Aug 1;211(3):333-342. doi: 10.4049/jimmunol.2300141.
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A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation.一种基于珠粒的高通量方法，用于绘制 T 细胞激活的序列和力依赖性图谱。
Nat Methods. 2022 Oct;19(10):1295-1305. doi: 10.1038/s41592-022-01592-2. Epub 2022 Sep 5.
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Mechanosurveillance: Tiptoeing T Cells.机械监视：蹑手蹑脚的 T 细胞。
Front Immunol. 2022 May 26;13:886328. doi: 10.3389/fimmu.2022.886328. eCollection 2022.
本文引用的文献
1
Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.通过 plexinD1-sema3E 轴对 β1 整合素黏附的动态控制。
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):379-84. doi: 10.1073/pnas.1314209111. Epub 2013 Dec 16.
2
Mechanical regulation of T-cell functions.T 细胞功能的机械调节。
Immunol Rev. 2013 Nov;256(1):160-76. doi: 10.1111/imr.12122.
3
2D TCR-pMHC-CD8 kinetics determines T-cell responses in a self-antigen-specific TCR system.2D TCR-pMHC-CD8 动力学决定了自身抗原特异性 TCR 系统中的 T 细胞反应。
Eur J Immunol. 2014 Jan;44(1):239-50. doi: 10.1002/eji.201343774. Epub 2013 Oct 20.
4
Mechanochemitry: a molecular biomechanics view of mechanosensing.机械化学：机械传感的分子生物力学视角
Ann Biomed Eng. 2014 Feb;42(2):388-404. doi: 10.1007/s10439-013-0904-5. Epub 2013 Sep 5.
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Initial activation of STIM1, the regulator of store-operated calcium entry.STIM1 的初始激活，是钙库操纵性钙内流的调节剂。
Nat Struct Mol Biol. 2013 Aug;20(8):973-81. doi: 10.1038/nsmb.2625. Epub 2013 Jul 14.
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Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.激动剂选择的 T 细胞发育需要强大的 T 细胞受体信号和储存操作的钙内流。
Immunity. 2013 May 23;38(5):881-95. doi: 10.1016/j.immuni.2013.02.008. Epub 2013 Mar 14.
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STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion.STIM2 通过轻度储存耗竭引起的储存操作型钙内流驱动 Ca2+ 震荡。
J Physiol. 2013 Mar 15;591(6):1433-45. doi: 10.1113/jphysiol.2012.245399. Epub 2013 Jan 28.
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The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.αβ T 细胞系免疫识别的结构基础：TCR 对接拓扑结构、机械转导和共受体功能。
Immunol Rev. 2012 Nov;250(1):102-19. doi: 10.1111/j.1600-065X.2012.01161.x.
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T cell triggering: insights from 2D kinetics analysis of molecular interactions.T 细胞激活：分子相互作用的 2D 动力学分析的新见解。
Phys Biol. 2012 Aug;9(4):045005. doi: 10.1088/1478-3975/9/4/045005. Epub 2012 Aug 7.
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Mechanosensing in T lymphocyte activation.T 淋巴细胞激活中的机械感知。
Biophys J. 2012 Jan 18;102(2):L5-7. doi: 10.1016/j.bpj.2011.12.011.
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