Zhu Cheng
Coulter Department of Biomedical Engineering, Woodruff School of Mechanical Engineering, and Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA,
Ann Biomed Eng. 2014 Feb;42(2):388-404. doi: 10.1007/s10439-013-0904-5. Epub 2013 Sep 5.
Molecular biomechanics includes two themes: the study of mechanical aspects of biomolecules and the study of molecular biology of the cell using mechanical tools. The two themes are interconnected for obvious reasons. The present review focuses on one of the interconnected areas-the mechanical regulation of molecular interaction and conformational change. Recent conceptual developments are summarized, including catch bonds, regulation of molecular interaction by the history of force application, and cyclic mechanical reinforcement. These studies elucidate the mechanochemistry of some of the candidate mechanosensing molecules, thereby providing a natural connection to mechanobiology.
生物分子力学方面的研究以及使用机械工具对细胞分子生物学的研究。出于显而易见的原因，这两个主题相互关联。本综述聚焦于其中一个相互关联的领域——分子相互作用和构象变化的力学调控。总结了近期的概念进展，包括捕获键、力施加历史对分子相互作用的调控以及循环机械增强。这些研究阐明了一些候选机械传感分子的机械化学，从而为力学生物学提供了自然的联系。
