成年男性银屑病的严重程度与吸烟有关，与饮酒无关。
Severity of Psoriasis Among Adult Males is Associated with Smoking, Not with Alcohol Use.
作者信息
Asokan N, Prathap Priya, Rejani Pp
机构信息
Department of Dermatology and Venereology, Government Medical College, Thrissur, Kerala, India.
Department of Psychiatry, Government Medical College, Thrissur, Kerala, India.
出版信息
Indian J Dermatol. 2014 May;59(3):237-40. doi: 10.4103/0019-5154.131382.
CONTEXT
Lifestyle factors such as tobacco smoking and alcohol use can affect the presentation and course of psoriasis. There is a paucity of data on this subject from India.
AIMS
To find out whether increased severity of psoriasis in adult Indian males is associated with tobacco smoking and alcohol use.
SETTINGS AND DESIGN
Cross-sectional study in the Department of Dermatology of a Tertiary Care Teaching Hospital.
SUBJECTS AND METHODS
Male patients above 18 years of age attending a psoriasis clinic between March 2007 and May 2009 were studied. Severity of psoriasis (measured using Psoriasis Area and Severity Index - PASI) among smokers and non-smokers was compared. We also studied the correlation between severity of psoriasis and nicotine dependence (measured using Fagerström Test for Nicotine Dependence) and alcohol use disorders (measured using Alcohol Use Disorders Identification Test-AUDIT).
STATISTICAL ANALYSIS
Z-test, Odd's ratio, Chi-square test, Spearman's correlation coefficient.
RESULTS
Of a total of 338 patients, 148 were smokers and 173 used to consume alcohol. Mean PASI score of smokers was more than that of non-smokers (Z-test, z = -2.617, P = 0.009). Those with severe psoriasis were more likely to be smokers (χ(2) = 5.47, P = 0.02, OR = 1.8, Confidence Interval 1.09-2.962). There was a significant correlation between PASI scores and Fagerström score (Spearman's correlation coefficient = 0.164, P < 0.01). Mean PASI scores of persons who used to consume alcohol and those who did not were comparable.(Z-test, z = -0.458, P = 0.647). There was no association between severity of psoriasis and alcohol consumption.(χ(2) = 0.255, P = 0.613, Odds Ratio = 1.14, CI 0.696-1.866). There was no correlation between PASI scores and AUDIT scores (Spearman's correlation coefficient = 0.024, P > 0.05).
CONCLUSIONS
Increased severity of psoriasis among adult males is associated with tobacco smoking, but not with alcohol use.
背景
吸烟和饮酒等生活方式因素会影响银屑病的表现和病程。印度在这方面的数据匮乏。
目的
探究成年印度男性银屑病病情加重是否与吸烟和饮酒有关。
设置与设计
在一家三级护理教学医院的皮肤科进行横断面研究。
研究对象与方法
对2007年3月至2009年5月期间到银屑病门诊就诊的18岁以上男性患者进行研究。比较吸烟者和非吸烟者的银屑病严重程度（采用银屑病面积和严重程度指数 - PASI进行测量）。我们还研究了银屑病严重程度与尼古丁依赖（采用尼古丁依赖弗格斯特罗姆测试进行测量）以及酒精使用障碍（采用酒精使用障碍识别测试 - AUDIT进行测量）之间的相关性。
统计分析
Z检验、优势比、卡方检验、斯皮尔曼相关系数。
结果
在总共338名患者中，148名是吸烟者，173名曾饮酒。吸烟者的平均PASI评分高于非吸烟者（Z检验，z = -2.617，P = 0.009）。重度银屑病患者更有可能是吸烟者（χ(2) = 5.47，P = 0.02，OR = 1.8，置信区间1.09 - 2.962）。PASI评分与弗格斯特罗姆评分之间存在显著相关性（斯皮尔曼相关系数 = 0.164，P < 0.01）。曾饮酒者和未饮酒者的平均PASI评分相当（Z检验，z = -0.458，P = 0.647）。银屑病严重程度与饮酒之间没有关联（χ(2) = 0.255，P = 0.613，优势比 = 1.14，CI 0.696 - 1.866）。PASI评分与AUDIT评分之间没有相关性（斯皮尔曼相关系数 = 0.024，P > 0.05）。
结论
成年男性银屑病病情加重与吸烟有关，但与饮酒无关。
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