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[多发伤患者凝血与输血治疗的当前实践:一项德国全国性在线调查]

[Current practice in coagulation and transfusion therapy in multiple trauma patients: A German nation-wide online survey].

作者信息

Wafaisade A, Wyen H, Mutschler M, Lendemans S, Bouillon B, Flohe S, Paffrath T, Maegele M, Tjardes T, Probst C

机构信息

Lehrstuhl für Unfallchirurgie, Orthopädie und Sporttraumatologie, Universität Witten/Herdecke am Klinikum Köln-Merheim, Ostmerheimer Straße 200, 51109, Köln, Deutschland.

Klinik für Unfall-, Hand- und Wiederherstellungschirurgie, Klinikum der J.W. Goethe-Universität, Frankfurt am Main, Deutschland.

出版信息

Unfallchirurg. 2015 Dec;118(12):1033-40. doi: 10.1007/s00113-014-2596-1.

Abstract

BACKGROUND

In recent years, the treatment of trauma-associated coagulopathy and bleeding has advanced enormously. The aim of this study was to assess the current practice of coagulation and transfusion management in Germany.

PATIENTS AND METHODS

From October 2011 until January 2012 we conducted a survey via online-questionnaire that was sent per E-Mail to all members of the German Society for Trauma Surgery. It comprised 12 questions with respect to current treatment of coagulopathy and haemorrhage in trauma patients.

RESULTS

The response rate was 145/3006 (5 %). The respondents had following specialties: 77.2 % trauma surgery 15.9 % anesthesiology, 6.9 % others. 64 % of respondents were employed by a Level 1 trauma centre, wheras 17 % worked in a local level 3 centre. The majority (94 %) claimed to treat hypothermia regularly. Only about half of the participants reported to follow a massive transfusion protocol in their institution. The potential components of these protocols were reported in varying rates, being it well-established components (e.g. FFP 78 %; Fibrinogen 75 %) or therapies with poor evidence in multiple trauma (Desmopressin 39 %, rFVIIa 47 %). Calcium was provided by only 48 % of respondents although generally recommended in all guidelines.

CONCLUSION

The current study suggests that in Germany strategies and principles regarding management of trauma-associated coagulopathy are standardized only poorly. Level 1 centres appear to apply a more advanced approach, however to much variability exists with respect to the components of the transfusion protocols. The low response rate indicates that most German trauma surgeons consider coagulation and hemorrhage as "expert-topics" beyond their field of duty.

摘要

背景

近年来,创伤相关凝血病和出血的治疗取得了巨大进展。本研究的目的是评估德国目前凝血和输血管理的实践情况。

患者与方法

2011年10月至2012年1月,我们通过在线问卷进行了一项调查,该问卷通过电子邮件发送给德国创伤外科学会的所有成员。问卷包含12个关于创伤患者凝血病和出血当前治疗的问题。

结果

回复率为145/3006(5%)。受访者的专业如下:创伤外科77.2%,麻醉学15.9%,其他6.9%。64%的受访者受雇于一级创伤中心,而17%在当地三级中心工作。大多数(94%)声称定期治疗体温过低。只有约一半的参与者报告称其所在机构遵循大量输血方案。这些方案的潜在组成部分报告率各不相同,既有成熟的组成部分(如新鲜冰冻血浆78%;纤维蛋白原75%),也有在多发伤中证据不足的疗法(去氨加压素39%,重组活化凝血因子VII 47%)。尽管所有指南普遍推荐,但只有48%的受访者提供钙。

结论

当前研究表明,在德国,创伤相关凝血病管理的策略和原则标准化程度很低。一级中心似乎采用了更先进的方法,然而输血方案的组成部分存在很大差异。低回复率表明,大多数德国创伤外科医生认为凝血和出血是超出其职责范围的“专家话题”。

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