牛中由BPV3变体和一种假定的BPV新亚型引起的混合乳头感染
Mixed Nipple Infections Caused by Variant of BPV3 and a Putative New Subtype of BPV in Cattle.
作者信息
He Z, Meng Q, Qiao J, Peng Y, Xie K, Liu Y, Cai X, Zhang J, Chen C
机构信息
College of Animal Science and Technology, Shihezi University, Shihezi, China.
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
出版信息
Transbound Emerg Dis. 2016 Feb;63(1):e140-3. doi: 10.1111/tbed.12238. Epub 2014 Jun 3.
Bovine papilloma is a chronic and proliferative skin and mucosal wart caused by Bovine papillomavirus (BPV). In June, 2013, a leaf-and flat-shaped wart disease was observed on the nipple skins in a cattle farm in Xinjiang. To diagnose the disease, we collected the diseased skins for pathological biopsy and DNA analysis by PCR amplification using a pair of degenerate primers FAP59 and FAP64. Sequencing and phylogenetic analysis showed that the infection was caused by a variant of BPV3 and putatively a new subtype of BPV (BPV/CHI-SW1, belonging to the Xi papillomavirus genus). This is the first report of mixed infection caused by variant of BPV3 and BPV (putatively new subtype) in China, and would be of importance for the molecular epidemiological study of the disease.
牛乳头瘤是由牛乳头瘤病毒（BPV）引起的一种慢性增殖性皮肤和黏膜疣。2013年6月，在新疆某养牛场的奶牛乳头皮肤上观察到一种叶状和平坦状的疣病。为诊断该病，我们采集了患病皮肤进行病理活检，并使用一对简并引物FAP59和FAP64通过PCR扩增进行DNA分析。测序和系统发育分析表明，该感染是由BPV3的一个变种引起的，推测为BPV的一个新亚型（BPV/CHI-SW1，属于Xi乳头瘤病毒属）。这是中国首次关于BPV3变种和BPV（推测为新亚型）混合感染的报道，对该病的分子流行病学研究具有重要意义。
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