School of Engineering Science, Simon Fraser University, Burnaby, British Columbia, Canada.
Department of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Invest Ophthalmol Vis Sci. 2014 Jun 3;55(7):4378-93. doi: 10.1167/iovs.14-14227.
To investigate morphological characteristics of optic nerve head and peripapillary region with myopia and glaucoma.
Ten normal and 17 glaucomatous myopic participants were imaged with a custom 1060-nm swept-source optical coherence tomography system. The three-dimensional images were processed and segmented for inner limiting membrane (ILM), posterior border of retinal nerve fiber layer (RNFL), Bruch's membrane (BM), and posterior border of choroid. Seven shape parameters were measured: nerve fiber layer (NFL) thickness; Bruch's membrane opening (BMO) area, eccentricity, and planarity; BMO and BM depths; and choroidal thickness. The results were analyzed by group and regional sector, and multiple regression was performed on each shape parameter with age, axial length, and glaucoma severity, measured by mean deviation (MD).
Bruch's membrane opening area (P < 0.001), eccentricity (P = 0.025), and planarity (P = 0.019) were correlated with axial length but not with MD, such that larger, more elliptical, and less planar BMO was associated with longer axial length. Several BMOs displayed a saddle-like shape configuration whose orientation appeared to be aligned with that of the BMO ellipse. All BM showed posterior deformation toward BMO such that BM closer to BMO was more posterior than that farther from BMO. Bruch's membrane depth was correlated with axial length (P = 0.014) and MD (P = 0.040) in intersubject regression, and BMO depth (P = 0.003) and BM depth (P = 0.006) were correlated with MD in intereye regression. Bruch's membrane depth was also associated with age. Choroidal thickness was negatively correlated with age (P = 0.001) and with axial length to a smaller degree (P = 0.034), but not with glaucoma severity.
Axial length was a significant factor in BMO and BM shape in normal and glaucomatous myopic subjects. Posterior deformation of BM was observed in all eyes and significantly associated with functional glaucomatous damage and age.
研究近视和青光眼患者视神经头和视盘周围形态特征。
使用定制的 1060nm 扫频源光学相干断层扫描系统对 10 名正常人和 17 名青光眼近视患者进行成像。对三维图像进行处理和分割，以获得内界膜（ILM）、视网膜神经纤维层（RNFL）后边界、Bruch 膜（BM）和脉络膜后边界。测量了 7 个形状参数：神经纤维层（NFL）厚度；Bruch 膜开口（BMO）面积、偏心度和平面度；BMO 和 BM 深度；脉络膜厚度。根据组和区域扇区进行分析，并对每个形状参数进行多元回归，以年龄、眼轴长度和平均偏差（MD）测量的青光眼严重程度为自变量。
Bruch 膜开口面积（P<0.001）、偏心度（P=0.025）和平面度（P=0.019）与眼轴长度相关，但与 MD 无关，较大、更椭圆和更不规则的 BMO 与较长的眼轴长度相关。一些 BMO 呈现出鞍状形状，其取向似乎与 BMO 椭圆的取向一致。所有 BM 均向 BMO 后变形，靠近 BMO 的 BM 比远离 BMO 的 BM 更靠后。BM 深度与眼间回归中的眼轴长度（P=0.014）和 MD（P=0.040）相关，BMO 深度（P=0.003）和 BM 深度（P=0.006）与 MD 相关。BM 深度也与年龄相关。脉络膜厚度与年龄（P=0.001）和眼轴长度（P=0.034）呈负相关，但与青光眼严重程度无关。
眼轴长度是正常和青光眼近视患者 BMO 和 BM 形态的重要因素。在所有眼中观察到 BM 的后变形，与功能性青光眼损伤和年龄显著相关。
