Rotundo Ligia Drovandi Braga, Toporcov Tatiana Natasha, Biazevic Gabriela Haye, de Carvalho Marcos Brasilino, Kowalski Luiz Paulo, Antunes José Leopoldo Ferreira
Faculdade de Odontologia, Universidade de Sao Paulo, SP, Brazil.
Hospital Heliopolis, Secretaria de Estado da Saude de Sao Paulo, SP, Brazil.
Rev Bras Epidemiol. 2013 Sep;16(3):705-15. doi: 10.1590/s1415-790x2013000300014.
This study aimed to assess the hypothesis that recurrent denture-related sores association may be associated with the risk of oral cancer.
We conducted a hospital-based case-control study comprising 71 new cases of oral cancer in two hospitals in São Paulo, Brazil, and 240 controls without cancer, recruited from outpatient units of the same hospitals. All cases had histologically confirmed squamous cell carcinoma in anatomic sites of the mouth that may be specifically consi-dered at risk of sores by ill-fitting dentures. Denture-related sores were assessed by the self-report of recurrent oral sores due to the use of ill-fitting complete removable dental prosthesis. Associations were assessed by multivariate logistic regression conditioned on socio-demographic and behavioral characteristics.
The association between ill-fitting dentures and oral cancer was statistically significant in the multivariate model: odds ratio 3.98; 95% confidence interval 1.06 - 14.96. The specific assessment of association between tumors in the lower jaw and sores by mandibular dentures confirmed this result: odds ratio 6.39; 95% confidence interval 1.49 - 29.52.
The potential contribution of denture-related sores to oral carcinogenesis still fuels controversies. This study reinfor-ces the hypothesis that recurrent denture-related sores may be associated with the risk of oral cancer. Results reported here also suggest that an appropriate application and monitoring of dental prosthesis represent a non-negligible scope for cancer prevention.
本研究旨在评估复发性义齿相关溃疡与口腔癌风险之间可能存在关联这一假设。
我们在巴西圣保罗的两家医院开展了一项基于医院的病例对照研究，纳入了71例口腔癌新发病例，以及从同医院门诊招募的240名无癌症的对照者。所有病例经组织学确诊为口腔解剖部位的鳞状细胞癌，这些部位可能因义齿佩戴不当而特别易患溃疡。通过自我报告因佩戴不合适的全口可摘义齿导致的复发性口腔溃疡来评估义齿相关溃疡。根据社会人口学和行为特征，通过多因素逻辑回归评估关联。
在多因素模型中，不合适的义齿与口腔癌之间的关联具有统计学意义：比值比为3.98；95%置信区间为1.06 - 14.96。对下颌肿瘤与下颌义齿溃疡之间关联的具体评估证实了这一结果：比值比为6.39；95%置信区间为1.49 - 29.52。
义齿相关溃疡对口腔致癌作用的潜在影响仍存在争议。本研究强化了复发性义齿相关溃疡可能与口腔癌风险相关的假设。此处报告的结果还表明，义齿的恰当应用和监测是癌症预防中不可忽视的方面。
