Jain Preet, Jain Meetu, Prasad B Vikas, Kakatkar Gauri S, Patel Maulik, Khan Javed
Department of Prosthodontics, Buraydah Colleges, Burhaydah Al Qassim, Kingdom of Saudi Arabia, Phone: +966576578455, e-mail:
Department of Periodontics, Buraydah Colleges, Burhaydah Al Qassim, Kingdom of Saudi Arabia.
J Contemp Dent Pract. 2016 Nov 1;17(11):930-933. doi: 10.5005/jp-journals-10024-1956.
Oral cancer is one of the most common cancers in the world. Although multifactorial, the exact pathogenesis of oral cancer is still unclear. Apart from tobacco chewing and smoking, chronic long-term irritation by ill-fitting denture is also said to be an important risk factor for the development of oral cancer. Literature quotes some amount of evidence that correlates long-term denture irritation as a risk factor for the development of oral cancer. Hence, we analyzed the correlation of denture-related sores as a risk factor for the development of oral cancer.
The present case-control study included 140 newly diagnosed oral cancer cases and 140 patients as the control healthy group. One-hour questionnaire was framed and was conducted to the control group and the study group by 10 experienced interviewers who were trained for such type of analysis. Assessment of the patients' socioeconomic status, cigarette smoking habit, alcohol drinking habit, and oral health status was done and compared on the two study groups. Logistic regression models along with multivariate models were used for the assessment of the results.
In the control group and the cancer patient group, total of 140 new cancer cases and 140 subjects were included. Out of 140 patients in the cancer group, 16 were nonsmokers, while 110 smoked cigarette in the cancer patient group. As far as alcohol consumption is concerned, 42 patients in the control group and 102 patients in the oral cancer group were chronic heavy drinkers. Fried food intake was high in both the groups. Significant correlation was obtained while comparing the heavy smokers, heavy alcohol consumers, and oral health status in both the study groups.
Our results favor the hypothesis that positive correlation exists between oral cancer risk and recurrent denture sores.
People wearing denture prosthesis should be periodically visualized for identification of any mucosal alteration or changes at the earliest.
口腔癌是世界上最常见的癌症之一。尽管其发病是多因素的，但口腔癌的确切发病机制仍不清楚。除了咀嚼烟草和吸烟外，不合适假牙的长期慢性刺激也被认为是口腔癌发生的一个重要危险因素。文献引用了一些证据，将长期假牙刺激与口腔癌发生的危险因素联系起来。因此，我们分析了假牙相关溃疡作为口腔癌发生危险因素的相关性。
本病例对照研究纳入140例新诊断的口腔癌病例和140例患者作为健康对照组。由10名经验丰富且经过此类分析培训的访谈者编制并对对照组和研究组进行了一小时的问卷调查。对两组患者的社会经济状况、吸烟习惯、饮酒习惯和口腔健康状况进行评估并比较。使用逻辑回归模型和多变量模型评估结果。
在对照组和癌症患者组中，共纳入140例新癌症病例和140名受试者。癌症组的140例患者中，16例不吸烟，而癌症患者组中有110例吸烟。就饮酒情况而言，对照组有42例患者，口腔癌组有102例患者为长期大量饮酒者。两组的油炸食品摄入量都很高。比较两组中的重度吸烟者、重度饮酒者和口腔健康状况时，获得了显著相关性。
我们的结果支持口腔癌风险与复发性假牙溃疡之间存在正相关的假设。
佩戴假牙修复体的人应定期进行检查，以便尽早发现任何黏膜改变或变化。
