补体系统与肺部疾病
Complement system in lung disease.
机构信息
1 Department of Microbiology and Immunology.
出版信息
Am J Respir Cell Mol Biol. 2014 Oct;51(4):467-73. doi: 10.1165/rcmb.2013-0485TR.
Abstract
In addition to its established contribution to innate immunity, recent studies have suggested novel roles for the complement system in the development of various lung diseases. Several studies have demonstrated that complement may serve as a key link between innate and adaptive immunity in a variety of pulmonary conditions. However, the specific contributions of complement to lung diseases based on innate and adaptive immunity are just beginning to emerge. Elucidating the role of complement-mediated immune regulation in these diseases will help to identify new targets for therapeutic interventions.
摘要
除了其在固有免疫中的既定作用外，最近的研究还表明补体系统在各种肺部疾病的发展中具有新的作用。一些研究表明，补体在多种肺部疾病中可能是先天免疫和适应性免疫之间的关键联系。然而，补体对基于先天免疫和适应性免疫的肺部疾病的具体贡献才刚刚开始显现。阐明补体介导的免疫调节在这些疾病中的作用将有助于确定治疗干预的新靶点。
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