Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, USA.
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, USA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, USA.
Matrix Biol. 2018 Nov;73:122-134. doi: 10.1016/j.matbio.2018.04.003. Epub 2018 Apr 9.
The lung harbors a complex immune system composed of both innate and adaptive immune cells. Recognition of infection and injury by receptors on lung innate immune cells is crucial for generation of antigen-specific responses by adaptive immune cells. The extracellular matrix of the lung, comprising the interstitium and basement membrane, plays a key role in the regulation of these immune systems. The matrix consists of several hundred assembled proteins that interact to form a bioactive scaffold. This template, modified by enzymes, acts to facilitate cell function and differentiation and changes dynamically with age and lung disease. Herein, we explore relationships between innate and adaptive immunity and the lung extracellular matrix. We discuss the interactions between extracellular matrix proteins, including glycosaminoglycans, with prominent effects on innate immune signaling effectors such as toll-like receptors. We describe the relationship of extracellular matrix proteins with adaptive immunity and leukocyte migration to sites of injury within the lung. Further study of these interactions will lead to greater knowledge of the role of matrix biology in lung immunity. The development of novel therapies for acute and chronic lung disease is dependent on a comprehensive understanding of these complex matrix-immunity interactions.
肺内存在着一个由固有免疫细胞和适应性免疫细胞组成的复杂免疫系统。肺固有免疫细胞上的受体对感染和损伤的识别，对于适应性免疫细胞产生抗原特异性反应至关重要。肺的细胞外基质，包括间质和基底膜，在调节这些免疫系统中起着关键作用。基质由几百种组装好的蛋白质组成，这些蛋白质相互作用形成一个具有生物活性的支架。该模板通过酶进行修饰，以促进细胞功能和分化，并随着年龄和肺部疾病的变化而动态变化。本文探讨了固有免疫和适应性免疫与肺细胞外基质之间的关系。我们讨论了细胞外基质蛋白（包括糖胺聚糖）与先天免疫信号效应器（如 Toll 样受体）之间的相互作用。我们描述了细胞外基质蛋白与适应性免疫以及白细胞向肺内损伤部位迁移的关系。对这些相互作用的进一步研究将有助于更好地了解基质生物学在肺免疫中的作用。急性和慢性肺部疾病的新型治疗方法的发展，依赖于对这些复杂的基质-免疫相互作用的全面理解。
