Jiang Yu, Xie Min, Chen Wenbin, Talbot Richard, Maddox Jillian F, Faraut Thomas, Wu Chunhua, Muzny Donna M, Li Yuxiang, Zhang Wenguang, Stanton Jo-Ann, Brauning Rudiger, Barris Wesley C, Hourlier Thibaut, Aken Bronwen L, Searle Stephen M J, Adelson David L, Bian Chao, Cam Graham R, Chen Yulin, Cheng Shifeng, DeSilva Udaya, Dixen Karen, Dong Yang, Fan Guangyi, Franklin Ian R, Fu Shaoyin, Guan Rui, Highland Margaret A, Holder Michael E, Huang Guodong, Ingham Aaron B, Jhangiani Shalini N, Kalra Divya, Kovar Christie L, Lee Sandra L, Liu Weiqing, Liu Xin, Lu Changxin, Lv Tian, Mathew Tittu, McWilliam Sean, Menzies Moira, Pan Shengkai, Robelin David, Servin Bertrand, Townley David, Wang Wenliang, Wei Bin, White Stephen N, Yang Xinhua, Ye Chen, Yue Yaojing, Zeng Peng, Zhou Qing, Hansen Jacob B, Kristensen Karsten, Gibbs Richard A, Flicek Paul, Warkup Christopher C, Jones Huw E, Oddy V Hutton, Nicholas Frank W, McEwan John C, Kijas James, Wang Jun, Worley Kim C, Archibald Alan L, Cockett Noelle, Xu Xun, Wang Wen, Dalrymple Brian P
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
CSIRO Animal Food and Health Sciences, St Lucia, QLD 4067, Australia.
Science. 2014 Jun 6;344(6188):1168-1173. doi: 10.1126/science.1252806.
Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.
绵羊（Ovis aries）是肉类、奶类以及羊毛形式纤维的主要来源，代表了一类具有特殊消化器官——瘤胃的独特动物群体，瘤胃负责植物材料的初始消化。我们开发并分析了高质量的绵羊参考基因组以及来自40种不同组织的转录组。我们鉴定出了与瘤胃进化相关的编码角蛋白交联蛋白的高表达基因。我们还鉴定出了参与脂质代谢的基因，这些基因发生了扩增和/或组织表达模式发生了改变。这可能是对皮肤屏障脂质变化、脂质代谢与羊毛合成之间的相互作用，以及与非反刍动物相比反刍动物中挥发性脂肪酸作用增强的一种响应。
