Padmanabhan Meenu S, Dinesh-Kumar Savithramma P
Department of Plant Biology and The Genome Center, College of Biological Sciences, University of California, Davis, CA 95616, United States.
Curr Opin Microbiol. 2014 Aug;20:55-61. doi: 10.1016/j.mib.2014.05.003. Epub 2014 Jun 4.
Plant innate immune response against viruses utilizes intracellular Nucleotide Binding domain Leucine Rich Repeat (NLR) class of receptors. NLRs recognize different viral proteins termed elicitors and initiate diverse signaling processes that induce programmed cell death (PCD) in infected cells and restrict virus spread. In this review we describe the recent advances made in the study of plant NLRs that detect viruses. We describe some of the physical and functional interactions these NLRs undertake. We elaborate on the intra-molecular and homotypic association of NLRs that function in self-regulation and activation. Nuclear role for some viral NLRs is discussed as well as the emerging importance of the RNAi pathway in regulating the NLR family.
植物针对病毒的先天免疫反应利用细胞内核苷酸结合结构域富含亮氨酸重复序列（NLR）类受体。NLR识别被称为激发子的不同病毒蛋白，并启动多种信号传导过程，这些过程会在受感染细胞中诱导程序性细胞死亡（PCD）并限制病毒传播。在这篇综述中，我们描述了检测病毒的植物NLR研究的最新进展。我们描述了这些NLR所进行的一些物理和功能相互作用。我们详细阐述了在自我调节和激活中起作用的NLR的分子内和同型关联。还讨论了一些病毒NLR的核作用以及RNAi途径在调节NLR家族中的新重要性。
