Hashimoto Masayoshi, Neriya Yutaro, Yamaji Yasuyuki, Namba Shigetou
Laboratory of Plant Pathology, Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo Tokyo, Japan.
Front Microbiol. 2016 Oct 26;7:1695. doi: 10.3389/fmicb.2016.01695. eCollection 2016.
The ability of plant viruses to propagate their genomes in host cells depends on many host factors. In the absence of an agrochemical that specifically targets plant viral infection cycles, one of the most effective methods for controlling viral diseases in plants is taking advantage of the host plant's resistance machinery. Recessive resistance is conferred by a recessive gene mutation that encodes a host factor critical for viral infection. It is a branch of the resistance machinery and, as an inherited characteristic, is very durable. Moreover, recessive resistance may be acquired by a deficiency in a negative regulator of plant defense responses, possibly due to the autoactivation of defense signaling. Eukaryotic translation initiation factor (eIF) 4E and eIF4G and their isoforms are the most widely exploited recessive resistance genes in several crop species, and they are effective against a subset of viral species. However, the establishment of efficient, recessive resistance-type antiviral control strategies against a wider range of plant viral diseases requires genetic resources other than eIF4Es. In this review, we focus on recent advances related to antiviral recessive resistance genes evaluated in model plants and several crop species. We also address the roles of next-generation sequencing and genome editing technologies in improving plant genetic resources for recessive resistance-based antiviral breeding in various crop species.
植物病毒在宿主细胞中传播其基因组的能力取决于许多宿主因子。在缺乏专门针对植物病毒感染周期的农用化学品的情况下，控制植物病毒病最有效的方法之一是利用宿主植物的抗性机制。隐性抗性由隐性基因突变赋予，该突变编码对病毒感染至关重要的宿主因子。它是抗性机制的一个分支，作为一种遗传特征，非常持久。此外，隐性抗性可能是由于植物防御反应的负调节因子缺乏而获得的，这可能是由于防御信号的自动激活。真核翻译起始因子（eIF）4E和eIF4G及其异构体是几种作物中应用最广泛的隐性抗性基因，它们对一部分病毒种类有效。然而，建立针对更广泛植物病毒病的高效隐性抗性型抗病毒控制策略需要eIF4E以外的遗传资源。在这篇综述中，我们重点关注在模式植物和几种作物中评估的抗病毒隐性抗性基因的最新进展。我们还讨论了下一代测序和基因组编辑技术在改善各种作物基于隐性抗性的抗病毒育种植物遗传资源方面的作用。
