Schoofs Andreas, Hückesfeld Sebastian, Surendran Sandya, Pankratz Michael J
Department of Molecular Brain Physiology, LIMES Institute, University of Bonn, Carl Troll Str. 31, 53115 Bonn, Germany.
Department of Molecular Brain Physiology, LIMES Institute, University of Bonn, Carl Troll Str. 31, 53115 Bonn, Germany.
J Insect Physiol. 2014 Oct;69:118-25. doi: 10.1016/j.jinsphys.2014.05.022. Epub 2014 Jun 4.
The enteric nervous system is critical for coordinating diverse feeding-related behaviors and metabolism. We have characterized a cluster of four serotonergic neurons in Drosophila larval brain: cell bodies are located in the subesophageal ganglion (SOG) whose neuronal processes project into the enteric nervous system. Electrophysiological, calcium imaging and behavioral analyses indicate a functional role of these neurons in modulating foregut motility. We suggest that the axonal projections of this serotonergic cluster may be part of a brain-gut neural pathway that is functionally analogous to the vertebrate vagus nerve.
肠神经系统对于协调各种与进食相关的行为和新陈代谢至关重要。我们已经对果蝇幼虫大脑中的一组四个血清素能神经元进行了特征描述：细胞体位于咽下神经节（SOG），其神经突起投射到肠神经系统中。电生理学、钙成像和行为分析表明这些神经元在调节前肠运动中发挥功能作用。我们认为这个血清素能神经元簇的轴突投射可能是一种脑-肠神经通路的一部分，该通路在功能上类似于脊椎动物的迷走神经。
