Division of Biological and Biomedical Sciences (BBS), College of Health & Life Sciences (CHLS), Hamad Bin Khalifa University (HBKU), Doha, 34110, Qatar.
J Neurodev Disord. 2021 Sep 15;13(1):37. doi: 10.1186/s11689-021-09378-x.
The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD.
肠道微生物群-脑轴（GUMBA）介导的通讯改变在自闭症等人类大脑疾病中起着关键作用，这一观点仍然是各个实验室研究的热点。胃肠道问题是自闭症谱系障碍（ASD）患者的常见合并症。尽管肠道微生物组和微生物代谢物已被牵连到 ASD 的病因中，但潜在的分子机制在很大程度上仍是未知的。在这篇综述中，我们总结了人类和动物模型中的最新发现，强调了肠道-大脑轴在 ASD 中的作用。我们讨论了果蝇作为研究 GUMBA 在 ASD 中作用的动物模型的遗传和神经行为特征。利用果蝇作为一种易于处理的遗传工具，结合无菌和定植方法，以及可利用的转基因果蝇，可能会揭示肠道微生物群-大脑相互作用的机制，并了解其改变对与 ASD 等神经紊乱相关行为的影响。
