The Education Ministry Key Lab of Resource Chemistry, Shanghai Normal University, Shanghai 200234, PR China; Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Normal University, Shanghai 200234, PR China.
Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China.
Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:196-205. doi: 10.1016/j.msec.2014.04.037. Epub 2014 Apr 26.
A multifunctional magnetic mesoporous bioactive glass (MMBG) has been widely used for a drug delivery system, but its biological properties have been rarely reported. Herein, the effects of mesopores and Fe3O4 nanoparticles on drug loading-release property, bactericidal property and biocompatibility have been investigated by using mesoporous bioactive glass (MBG) and non-mesoporous bioactive glass (NBG) as control samples. Both MMBG and MBG have better drug loading efficiency than NBG because they possess ordered mesoporous channels, big specific surface areas and high pore volumes. As compared with MBG, the Fe3O4 nanoparticles in MMBG not only provide magnetic property, but also improve sustained drug release property. For gentamicin-loaded MMBG (Gent-MMBG), the sustained release of gentamicin and the Fe3O4 nanoparticles minimize bacterial adhesion significantly and prevent biofilm formation against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Moreover, the magnetic Fe3O4 nanoparticles in MMBG can promote crucial cell functions such as cell adhesion, spreading and proliferation. The excellent biocompatibility and drug delivery property of MMBG suggest that Gent-MMBG has great potentials for treatment of implant-associated infections.
一种多功能磁性介孔生物活性玻璃（MMBG）已被广泛应用于药物输送系统，但它的生物学性质却鲜有报道。本文以介孔生物活性玻璃（MBG）和非介孔生物活性玻璃（NBG）为对照样品，研究了介孔和 Fe3O4 纳米粒子对载药-释药性能、杀菌性能和生物相容性的影响。由于具有有序介孔通道、较大的比表面积和较高的孔体积，MMBG 和 MBG 均具有更好的载药效率。与 MBG 相比，MMBG 中的 Fe3O4 纳米粒子不仅提供了磁性，还改善了药物的持续释放性能。对于载庆大霉素的 MMBG（Gent-MMBG），庆大霉素和 Fe3O4 纳米粒子的持续释放显著减少了金黄色葡萄球菌（S. aureus）和表皮葡萄球菌（S. epidermidis）的细菌黏附，并防止生物膜形成。此外，MMBG 中的磁性 Fe3O4 纳米粒子可以促进细胞的关键功能，如细胞黏附、铺展和增殖。MMBG 具有优异的生物相容性和药物输送性能，表明 Gent-MMBG 在治疗植入物相关感染方面具有巨大的潜力。
