Dpto. Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, 15782 Spain.
Dpto. Física Aplicada, E.E. Industriais, Universidade de Vigo, Vigo, Spain.
Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:232-9. doi: 10.1016/j.msec.2014.04.058. Epub 2014 May 2.
Direct contact of materials with blood components may trigger numerous processes which ultimately lead to hemolysis, clot formation and recruitment of inflammatory cells. In this study, the blood-surface interactions for two inert bioinspired ceramic scaffolds obtained from natural resources; biomorphic carbon and silicon carbides (bioSiC) from different origins have been studied. The response of the blood in contact with carbon is well known, however little has been identified on the influence of their 3D porous structure. Moreover, to our knowledge, there is no reference in the literature about the hemocompatibility of biomorphic silicon carbide as a porous scaffold. The experimental results showed the surface energy to be crucial to evaluate the hemocompatibility of a material however the surface topography and material porosity are also parameters to be considered. Surface roughness modifies clot formation whereas for protein adsorption total sample porosity seems to be the key parameter to be considered for hydrophilic materials (biomorphic silicon carbides), while the size of the pores determines the hemolytic response.
材料与血液成分的直接接触可能引发许多过程，最终导致溶血、血栓形成和炎症细胞的募集。在这项研究中，研究了两种源自天然资源的惰性仿生陶瓷支架的血液-表面相互作用；形态碳和硅 carbide（bioSiC）来自不同的起源。与碳接触的血液的反应是众所周知的，但是对于它们的 3D 多孔结构的影响，却知之甚少。此外，据我们所知，文献中没有关于形态硅 carbide 作为多孔支架的血液相容性的参考。实验结果表明，表面能对于评估材料的血液相容性至关重要，但是表面形貌和材料孔隙率也是需要考虑的参数。表面粗糙度会改变血栓形成，而对于蛋白质吸附，总样品孔隙率似乎是亲水材料（形态硅 carbide）的关键参数，而孔隙大小决定了溶血反应。
