Aderemi-Williams R I, Awodele O, Boyle C A
Department of Pharmacology, Therapeutics & Toxicology, College of Medicine, University of Lagos, P.M.B 12003, Idi-araba, Lagos, Nigeria.
Curr Drug Saf. 2015;10(2):136-44. doi: 10.2174/1574886309666140601211211.
Adverse drug reaction (ADR) is a global drug therapy problem. It has been rated as one of the top leading causes of morbidity and mortality. In Nigeria, not much is known about ADRs especially with the existing weak post marketing surveillance for monitoring drug use, and its effect on the population.
The study is aimed at determining the incidence of ADRs, presentations of ADRs, classes of drugs that frequently cause ADRs and predictors of ADRs in adult medical in-patients in LASUTH.
A retrospective study of six hundred and twenty four (624) case notes of all patients admitted to the medical wards in LASUTH between January 1, 2009 and December 31, 2009 was carried out. Information obtained included age, gender, and adverse drug reaction and drug details. The results obtained were analyzed using SPSS version 16 statistical software. Level of significance was set at p ≤ 0.05.
A total of 624 case notes consisting of 358 males and 266 females were assessed. The number of patients who experienced adverse drug reactions was 67 (n = 624, 10.7%). The incidence rate of ADRs in LASUTH from the study was 10.7 per 100 patients' population. Most of the ADRs observed were type A reactions (97.8%). Mostly implicated classes of drugs were antidiabetics (26.7%) and NSAIDs (29.3%).
The incidence rate of ADRs was 10.7%. ADRs which are predictable and preventable occur in hospitalized patients, such may be prevented or minimized by implementing measures to target specific drugs that are commonly suspected.
药物不良反应（ADR）是一个全球性的药物治疗问题。它已被列为发病和死亡的主要原因之一。在尼日利亚，人们对药物不良反应了解不多，尤其是在现有的药品上市后监测薄弱、难以监测药物使用及其对人群影响的情况下。
本研究旨在确定拉各斯大学教学医院（LASUTH）成年内科住院患者中药物不良反应的发生率、药物不良反应的表现形式、经常引起药物不良反应的药物类别以及药物不良反应的预测因素。
对2009年1月1日至2009年12月31日期间在LASUTH内科病房住院的所有患者的624份病例记录进行回顾性研究。获得的信息包括年龄、性别、药物不良反应和药物详细信息。使用SPSS 16版统计软件对所得结果进行分析。显著性水平设定为p≤0.05。
共评估了624份病例记录，其中男性358例，女性266例。发生药物不良反应的患者有67例（n = 624，10.7%）。该研究中LASUTH的药物不良反应发生率为每100名患者中有10.7例。观察到的大多数药物不良反应为A型反应（97.8%）。最常涉及的药物类别是抗糖尿病药（26.7%）和非甾体抗炎药（29.3%）。
药物不良反应的发生率为10.7%。可预测和可预防的药物不良反应发生在住院患者中，通过实施针对常见可疑特定药物的措施，此类不良反应可能会得到预防或最小化。
