人胎盘/脐血细胞移植治疗大鼠严重脊髓损伤的效率
Efficiency of transplantation of human placental/umbilical blood cells to rats with severe spinal cord injury.
作者信息
Ryabov S I, Zvyagintseva M A, Pavlovich E R, Smirnov V A, Grin' A A, Chekhonin V P
机构信息
Russian Cardiology Research-and-Production Complex, Ministry of Health of the Russian Federation, Moscow, Russia,
出版信息
Bull Exp Biol Med. 2014 May;157(1):85-8. doi: 10.1007/s10517-014-2498-9. Epub 2014 Jun 10.
The effects of a single intravenous injection of human umbilical blood were studied on the model of severe spinal cord contusion injury in rats. Rats receiving no umbilical blood (spontaneous recovery) served as the control. All rats exhibited pronounced hind limb paraplegia and autonomic dysfunction of pelvic organs after the injury. Recovery of the hind limb function was evaluated by loading tests and locomotor activity testing in the open field using BBB score for open-field testing. Testing was carried out weekly for 8 weeks after the injury. Open-field testing showed a significant (p < 0.05) increase of the rate and volume of the hind limb motor activity recovery in the groups receiving umbilical blood infusions.
在大鼠严重脊髓挫伤损伤模型上研究了单次静脉注射人脐血的效果。未接受脐血注射（自发恢复）的大鼠作为对照。所有大鼠在损伤后均表现出明显的后肢截瘫和盆腔器官自主神经功能障碍。通过负重试验和旷场运动活动测试，使用旷场测试的BBB评分评估后肢功能的恢复情况。损伤后每周进行一次测试，持续8周。旷场测试显示，接受脐血输注的组后肢运动活动恢复的速率和量显著增加（p < 0.05）。
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