信使核糖核酸（mRNA）聚腺苷酸（poly(A)）尾大小的决定因素及影响——这种蛋白质会让我的尾巴看起来很大吗？
Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?
作者信息
Jalkanen Aimee L, Coleman Stephen J, Wilusz Jeffrey
机构信息
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Semin Cell Dev Biol. 2014 Oct;34:24-32. doi: 10.1016/j.semcdb.2014.05.018. Epub 2014 Jun 5.
Abstract
While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.
摘要
虽然聚腺苷酸化现象已得到充分研究，但聚（A）尾长度的动态变化及其对转录本功能和细胞生物学的影响却鲜为人知。本综述的目的是鼓励读者将聚（A）尾视为转录本的一个动态、可变的方面，而不是一个简单的标记mRNA 3'端的静态实体。这可能会在整个发育、分化和癌症过程中基因表达的转录后调控方面开辟新的调控角度。
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