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本文引用的文献

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Poly(A) RNA-binding proteins and polyadenosine RNA: new members and novel functions.多聚（A）RNA 结合蛋白和多聚腺苷酸 RNA：新成员和新功能。
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Sizing up the poly(A) tail: insights from deep sequencing.评估聚腺苷酸尾：来自深度测序的见解
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Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements.富含AU和富含GU元件对细胞因子信号传导的转录后调控。
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A conserved role for the zinc finger polyadenosine RNA binding protein, ZC3H14, in control of poly(A) tail length.锌指多腺苷 RNA 结合蛋白 ZC3H14 在控制多聚（A）尾长中的保守作用。
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Poly(A) polymerase-based poly(A) length assay.基于聚腺苷酸聚合酶的聚腺苷酸长度测定
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Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements.Dnmt1 的有效翻译需要细胞质多聚腺苷酸化和 Musashi 结合元件。
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TAIL-seq: genome-wide determination of poly(A) tail length and 3' end modifications.TAIL-seq：全基因组测定多聚（A）尾长度和 3'末端修饰。
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Poly(A)-tail profiling reveals an embryonic switch in translational control.多聚（A）尾谱分析揭示了翻译控制中的胚胎转换。
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Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation.细胞质多聚（A）结合蛋白 C4 在红细胞分化中起着关键作用。
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信使核糖核酸（mRNA）聚腺苷酸（poly(A)）尾大小的决定因素及影响——这种蛋白质会让我的尾巴看起来很大吗？

Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?

作者信息

Jalkanen Aimee L, Coleman Stephen J, Wilusz Jeffrey

机构信息

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

出版信息

Semin Cell Dev Biol. 2014 Oct;34:24-32. doi: 10.1016/j.semcdb.2014.05.018. Epub 2014 Jun 5.

DOI:10.1016/j.semcdb.2014.05.018
PMID:24910447
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4163081/
Abstract

While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.

摘要

虽然聚腺苷酸化现象已得到充分研究，但聚（A）尾长度的动态变化及其对转录本功能和细胞生物学的影响却鲜为人知。本综述的目的是鼓励读者将聚（A）尾视为转录本的一个动态、可变的方面，而不是一个简单的标记mRNA 3'端的静态实体。这可能会在整个发育、分化和癌症过程中基因表达的转录后调控方面开辟新的调控角度。