Martínez-Levy Gabriela A, Cruz-Fuentes Carlos S
Psychiatric Genetics Department, Clinical Research Branch, National Institute of Psychiatry Ramón de la Fuente Muñíz, Mexico City, Mexico.
Yale J Biol Med. 2014 Jun 6;87(2):173-86. eCollection 2014 Jun.
The BDNF is required for the development and proper function of the central nervous system, where it is involved in a variety of neural and molecular events relevant to cognition, learning, and memory processes. Although only a functional mature protein is synthesized, the human BDNF gene possesses an extensive structural complexity, including the presence of multiple promoters, splicing events, and 3´UTR poly-adenylation sites, resulting in an intricate transcriptional regulation and numerous messengers RNA. Recent data support specific cellular roles of these transcripts. Moreover, a central role of epigenetic modifications on the regulation of BDNF gene transcription is also emerging. The present essay aims to summarize the published information on the matter, emphasizing their possible implications in health and disease or in the treatment of different neurologic and psychiatric disorders.
脑源性神经营养因子（BDNF）是中枢神经系统发育及正常功能所必需的，它参与了与认知、学习和记忆过程相关的多种神经和分子活动。虽然只合成功能性成熟蛋白，但人类BDNF基因具有广泛的结构复杂性，包括存在多个启动子、剪接事件和3´非翻译区（UTR）聚腺苷酸化位点，导致复杂的转录调控和众多信使核糖核酸。最近的数据支持了这些转录本的特定细胞作用。此外，表观遗传修饰在BDNF基因转录调控中的核心作用也日益显现。本文旨在总结关于这一问题的已发表信息，强调它们在健康和疾病或不同神经和精神疾病治疗中的可能影响。
