Zheng YanSong, Liu MinYan, Shu Hua, Chen ZhiLai, Liu GuiXia, Zhang YeYing
The Chinese People's Liberation Army General Hospital Health Management Institute, FuXing Road 28, Beijing 100853, China.
Department of Geriatric Endocrinology, The Chinese People's Liberation Army General Hospital, Beijing 100853, China.
Arch Oral Biol. 2014 Sep;59(9):938-43. doi: 10.1016/j.archoralbio.2014.05.020. Epub 2014 May 24.
The aim of this study is to investigate the relationship between oral problems and Helicobacter pylori (Hp) infection, and to reveal which oral problems are significantly related with Hp infection.
Participants undergoing healthy medical examination were examined for 12 kinds of oral problems: dental calculus, oral mucosal disease, periodontal disease, decayed tooth, tooth defect, disuse tooth, residual crown and root, devital tooth, loose tooth, fistula, ill-fitting fixed denture and ectopic tooth. Hp infection was confirmed by (13)C-urea breath test. Participant information including age, educational level, smoking habits, drinking habits, height, weight and body mass index (BMI) were collected using a standard questionnaire.
Hp infection was 46.97% of the 54,036 cases. Age (P<0.01), gender (P<0.001) and BMI (P<0.01) were significantly associated with Hp infection. Smoking (P<0.001) and regular drinking (P<0.001) were showed to be associated with Hp infection. After adjustments for other associated factors, in all of the 12 oral problems, only dental calculus [n=35,559, OR (95% CI)=1.05 (1.01-1.09), P=0.012] and loose tooth [n=2411, OR (95% CI)=1.22 (1.03-1.22), P=0.007] were related with Hp infection.
In a cross-sectional analysis, the prevalence of Hp infection was strongly related with several social problems, including age, gender, BMI, smoking and regular drinking. In addition, oral problems, particularly dental calculus and loose tooth, were found to be associated with Hp infection, possibly due to the dental plaque. The study suggested that to prevent or eradicate Hp infection, we need to focus on oral hygiene and prevention of oral problems, especially dental calculus and loose tooth.
本研究旨在探讨口腔问题与幽门螺杆菌（Hp）感染之间的关系，并揭示哪些口腔问题与Hp感染显著相关。
对接受健康体检的参与者进行12种口腔问题检查：牙结石、口腔黏膜病、牙周病、龋齿、牙齿缺损、废用牙、残冠残根、死髓牙、松动牙、瘘管、固定义齿修复不良和异位牙。通过（13）C-尿素呼气试验确认Hp感染。使用标准问卷收集参与者的信息，包括年龄、教育程度、吸烟习惯、饮酒习惯、身高、体重和体重指数（BMI）。
54036例中Hp感染率为46.97%。年龄（P<0.01）、性别（P<0.001）和BMI（P<0.01）与Hp感染显著相关。吸烟（P<0.001）和经常饮酒（P<0.001）与Hp感染有关。在对其他相关因素进行调整后，在所有12种口腔问题中，只有牙结石[n=35559，OR（95%CI）=1.05（1.01-1.09），P=0.012]和松动牙[n=2411，OR（95%CI）=1.22（1.03-1.22），P=0.007]与Hp感染有关。
在横断面分析中，Hp感染率与几个社会问题密切相关，包括年龄、性别、BMI、吸烟和经常饮酒。此外，发现口腔问题，特别是牙结石和松动牙，与Hp感染有关，可能是由于牙菌斑。该研究表明，为预防或根除Hp感染，我们需要关注口腔卫生和预防口腔问题，特别是牙结石和松动牙。
