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癌症研究中的超微弱延迟发光:基于阿瑞图萨设备的结果综述

Ultra-weak delayed luminescence in cancer research: a review of the results by the ARETUSA equipment.

作者信息

Scordino Agata, Baran Irina, Gulino Marisa, Ganea Constanta, Grasso Rosaria, Niggli J Hugo, Musumeci Francesco

机构信息

Physics and Astronomy Department, University of Catania, Catania, Italy; National Southern Laboratories, National Nuclear Physics Institute, Catania, Italy.

Dept. of Biophysics, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

出版信息

J Photochem Photobiol B. 2014 Oct 5;139:76-84. doi: 10.1016/j.jphotobiol.2014.03.027. Epub 2014 May 20.

Abstract

The study of the photoinduced ultraweak photon emission in the optical wavelength range, namely the Delayed Luminescence, from human cells and tissues has an increasingly growing interest in view of its possible application in optical biopsy. Due to the low level, dedicated experimental set-up are necessary to reveal such photoluminescence signal. The paper reviews the results obtained in the field of cancer research, by using the experimental equipment for fast ultraweak luminescence analysis ARETUSA developed at the National Southern Laboratories of the National Nuclear Physics Institute (LNS-INFN), in Catania, Italy. Delayed Luminescence signals from normal and cancer cells are compared and the relationship between Delayed Luminescence and apoptosis is investigated.

摘要

鉴于光诱导超微弱光子发射在光学活检中的潜在应用,对其在光学波长范围内(即延迟发光)从人体细胞和组织中的研究兴趣日益浓厚。由于该信号水平较低,需要专门的实验装置来揭示这种光致发光信号。本文回顾了利用位于意大利卡塔尼亚的国家核物理研究所南方实验室(LNS-INFN)开发的用于快速超微弱发光分析的ARETUSA实验设备,在癌症研究领域所取得的成果。比较了正常细胞和癌细胞的延迟发光信号,并研究了延迟发光与细胞凋亡之间的关系。

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