Shin Hyun Tae, Kim Jun Hwan, Shim Joonho, Lee Jong Hee, Lee Dong Youn, Lee Joo Heung, Yang Jun Mo
Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine , Seoul , Korea.
J Dermatolog Treat. 2015 Jun;26(3):246-51. doi: 10.3109/09546634.2014.933163. Epub 2014 Jul 9.
Photodynamic therapy (PDT) with intense pulsed light (IPL) was proven effective for photorejuvenation. Recently, a new formulation of 0.5% 5-aminolevulinic acid (ALA) liposomal spray has been available. We designed a randomized split face study to evaluate usefulness and safety of IPL-PDT using a liposomal spray for periorbital wrinkles in Asians.
Patients received three treatments every 3 weeks. The half of the face was treated with IPL-PDT and the other half with long pulsed Nd:YAG laser (LPNY). Skin fluorescence was measured using a spectrophotometer for the guidance of PDT treatment. Wrinkle score was marked by two-blinded independent dermatologists.
One patient dropped out due to 3-d lasting erythema on PDT side. The difference of mean reduction in lower and lateral periorbital wrinkle score on PDT side between the first and the last visit was statistically significant (p = 0.008 and p = 0.001, respectively). Lateral periorbital wrinkles treated with PDT showed better results than LPNY-treated sides. Twenty-five percent of patients reported good to excellent outcomes.
This study demonstrated that PDT with a liposomal spray provided modest wrinkle reduction without serious adverse effect and it might be a promising treatment modality for wrinkle treatment in Asians.
强脉冲光（IPL）光动力疗法（PDT）已被证明对嫩肤有效。最近，一种新的0.5% 5-氨基酮戊酸（ALA）脂质体喷雾制剂已上市。我们设计了一项随机半脸研究，以评估使用脂质体喷雾进行IPL-PDT治疗亚洲人眶周皱纹的有效性和安全性。
患者每3周接受3次治疗。半侧面部接受IPL-PDT治疗，另一侧接受长脉冲Nd:YAG激光（LPNY）治疗。使用分光光度计测量皮肤荧光，以指导PDT治疗。皱纹评分由两名独立的皮肤科医生进行双盲评定。
1例患者因PDT侧出现持续3天的红斑而退出。PDT侧首次和末次就诊时眶周下部和外侧皱纹评分的平均降低差异具有统计学意义（分别为p = 0.008和p = 0.001）。PDT治疗的眶周外侧皱纹比LPNY治疗侧效果更好。25%的患者报告效果良好至极佳。
本研究表明，脂质体喷雾PDT可适度减少皱纹，且无严重不良反应，可能是亚洲人皱纹治疗的一种有前景的治疗方式。
