Petelin Ana, Bizjak Mojca, Černelič-Bizjak Maša, Jurdana Mihaela, Jakus Tadeja, Jenko-Pražnikar Zala
Faculty of Health Sciences, University of Primorska, Polje 42, SI-6310, Izola, Slovenia.
J Endocrinol Invest. 2014 Aug;37(8):745-755. doi: 10.1007/s40618-014-0102-9. Epub 2014 Jun 10.
Low-grade systemic inflammation due to obesity is considered to be the key link between obesity and obesity-related disorders. The hypothesis was tested that significant alterations in inflammatory markers and adipokines would occur over a multidisciplinary intervention and that these changes might also be important for improvement of cardiovascular risk factors.
Thirty-tree overweight adults completed a 6-month multidisciplinary intervention program to evaluate the effects of a personalized dietary program based on the individual's resting metabolic rate (RMR) on anthropometric parameters, aerobic and anaerobic capabilities, metabolic profile, inflammation, and body image satisfaction. Body composition, physical activity, anaerobic capabilities, RMR, metabolic profile, and low-grade inflammation were measured. Diet composition and body image dissatisfaction were also assessed.
After 6 months of multidisciplinary intervention the participants showed significantly decreased body weight, waist circumference (WC), and the inflammatory markers tumor necrosis factor-α, C-reactive protein, and visfatin. They also showed increased anti-inflammatory adiponectin and consequently decreased serum insulin, HOMA-IR, and total cholesterol. The important findings of the study were that reduction of sugars and saturated fatty acids in the diet, coupled with an increase in exercise, significantly correlated with reduction of WC and body mass index. In addition, positive correlations between ∆ BMI, ∆ WC, ∆ trunk fat, inflammation, and cardiovascular risk factors were demonstrated.
Weight loss in combination with increased physical activity, a negative energy balance, and diet adjustment was associated with lower inflammation and consequently with lower cardiovascular risk factors.
肥胖所致的低度全身炎症被认为是肥胖与肥胖相关疾病之间的关键联系。本研究检验了这样一个假设，即在多学科干预过程中，炎症标志物和脂肪因子会发生显著变化，且这些变化可能对改善心血管危险因素也很重要。
33名超重成年人完成了一项为期6个月的多学科干预项目，以评估基于个体静息代谢率（RMR）的个性化饮食计划对人体测量参数、有氧和无氧能力、代谢状况、炎症及身体形象满意度的影响。测量了身体成分、身体活动、无氧能力、RMR、代谢状况和低度炎症。还评估了饮食组成和身体形象不满情况。
经过6个月的多学科干预，参与者的体重、腰围（WC）以及炎症标志物肿瘤坏死因子-α、C反应蛋白和内脂素均显著降低。他们还表现出抗炎性脂联素增加，从而血清胰岛素、HOMA-IR和总胆固醇降低。该研究的重要发现是，饮食中糖和饱和脂肪酸的减少，再加上运动的增加，与WC和体重指数的降低显著相关。此外，还证明了体重指数变化（∆BMI）、腰围变化（∆WC）、躯干脂肪变化（∆躯干脂肪）、炎症与心血管危险因素之间存在正相关。
体重减轻与身体活动增加、负能量平衡和饮食调整相结合，与较低的炎症相关，从而与较低的心血管危险因素相关。
