Piccolo Luca Lo, Corona Davide, Onorati Maria Cristina
Dipartimento STEBICEF, Istituto Telethon Dulbecco c/o Universita' degli Studi di Palermo, 90128, Palermo, Italy,
Chromosoma. 2014 Dec;123(6):515-27. doi: 10.1007/s00412-014-0470-0. Epub 2014 Jun 10.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a highly conserved family of RNA-binding proteins able to associate with nascent RNAs in order to support their localization, maturation and translation. Research over this last decade has remarked the importance of gene regulatory processes at post-transcriptional level, highlighting the emerging roles of hnRNPs in several essential biological events. Indeed, hnRNPs are key factors in regulating gene expression, thus, having a number of roles in many biological pathways. Moreover, failure of the activities catalysed by hnRNPs affects various biological processes and may underlie several human diseases including cancer, diabetes and neurodegenerative syndromes. In this review, we summarize some of hnRNPs' roles in the model organism Drosophila melanogaster, particularly focusing on their participation in all aspects of post-transcriptional regulation as well as their conserved role and involvement in the aetiology of human pathologies.
不均一核核糖核蛋白（hnRNPs）是一类高度保守的RNA结合蛋白家族，能够与新生RNA结合，以支持其定位、成熟和翻译。过去十年的研究表明了转录后水平基因调控过程的重要性，突出了hnRNPs在若干重要生物学事件中不断显现的作用。事实上，hnRNPs是调节基因表达的关键因子，因此在许多生物学途径中发挥着多种作用。此外，hnRNPs催化的活性失败会影响各种生物学过程，并可能成为包括癌症、糖尿病和神经退行性综合征在内的多种人类疾病的基础。在这篇综述中，我们总结了hnRNPs在模式生物黑腹果蝇中的一些作用，特别关注它们在转录后调控各个方面的参与情况，以及它们在人类病理学病因学中的保守作用和参与情况。
