Oncology Research Center, Federal University of Pará, Belém 66073-000, Pará, Brazil.
Ophir Loyola Hospital, Molecular Biology Laboratory, Belém 66063-240, Pará, Brazil.
Genes (Basel). 2023 Feb 9;14(2):453. doi: 10.3390/genes14020453.
Gastric cancer (GC) is the fifth most common type of cancer and the fourth leading cause of cancer death. In Brazil, GC has a high incidence and mortality rates, and it is highly variable by region. The Amazon region has significant rising rates among all Brazil regions. Only very few studies have evaluated the association between genetic variants and the risk of gastric cancer in the Brazilian Amazon population. Therefore, this study aimed to investigate associations between single nucleotide polymorphisms of miRNA processing genes and the risk for GC in this population. Potentially functional single nucleotide polymorphisms from miRNA processing genes were genotyped in 159 cases and 193 healthy controls by QuantStudio Real Time PCR. According to our findings, the genotype GG of the variant rs10739971 presents a lower risk to the development of GC in comparison to the remaining genotypes ( = 0.000016; OR = 0.055; 95% CI = 0.015-0.206). This is the first study to report the association of pri-let-7a-1 rs10739971 with GC in the Brazilian Amazon population, which is a highly mixed population with a unique genetic constitution that is different from other populations that are studied in the vast majority of scientific research.
胃癌（GC）是第五种最常见的癌症类型，也是第四大癌症死亡原因。在巴西，GC 的发病率和死亡率都很高，而且在不同地区差异很大。亚马逊地区的发病率在所有巴西地区中呈显著上升趋势。只有极少数研究评估了遗传变异与巴西亚马逊地区人群胃癌风险之间的关系。因此，本研究旨在探讨 miRNA 加工基因单核苷酸多态性与该人群 GC 风险之间的关联。通过 QuantStudio Real Time PCR 对 159 例病例和 193 例健康对照者的 miRNA 加工基因的潜在功能单核苷酸多态性进行了基因分型。根据我们的发现，与其余基因型相比，变异 rs10739971 的基因型 GG 发生 GC 的风险较低（ = 0.000016；OR = 0.055；95%CI = 0.015-0.206）。这是第一项报道 pri-let-7a-1 rs10739971 与巴西亚马逊人群 GC 相关的研究，该人群是一个高度混合的人群，具有独特的遗传构成，与绝大多数科学研究中研究的其他人群不同。
