He Chunyan, Chen Xiaohui, Zhao Chunyang, Qie Yanyan, Yan Zhaowei, Zhu Xueming
Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Inflammation. 2014 Oct;37(5):1533-43. doi: 10.1007/s10753-014-9880-7.
Rheumatoid arthritis is the most common arthritis and is mainly characterized by symmetric polyarticular joint disorders. Eleutheroside E (EE), a principal active constituent of Acanthopanax senticosus, is reported to have anti-inflammatory effect by inhibiting NF-κB activities. However, the effects of EE on rheumatoid arthritis (RA) severity are largely unknown. The purpose of this study was to indicate whether EE could ameliorate arthritis and reduce inflammatory cytokine release in collagen-induced arthritis (CIA) mice. The results showed that EE attenuated the severity of arthritis by reducing the mean arthritis score and arthritis incidence. EE also significantly decreased the inflammatory cell infiltration, pannus formation, cartilage damage, and bone erosion of CIA mice. Furthermore, EE caused a marked decrease of the production of TNF-α and IL-6 in vivo and in vitro. These observations identify a novel function of EE that results in inhibition of cytokine release, highlighting EE was a potential therapeutic agent for RA.
类风湿性关节炎是最常见的关节炎，主要特征为对称性多关节紊乱。刺五加苷E（EE）是刺五加的主要活性成分，据报道其通过抑制核因子κB（NF-κB）活性发挥抗炎作用。然而，EE对类风湿性关节炎（RA）严重程度的影响在很大程度上尚不清楚。本研究的目的是表明EE是否能改善胶原诱导性关节炎（CIA）小鼠的关节炎并减少炎性细胞因子释放。结果显示，EE通过降低平均关节炎评分和关节炎发病率减轻了关节炎的严重程度。EE还显著减少了CIA小鼠的炎性细胞浸润、血管翳形成、软骨损伤和骨侵蚀。此外，EE在体内和体外均导致肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的产生显著减少。这些观察结果确定了EE的一种新功能，即抑制细胞因子释放，突出表明EE是RA的一种潜在治疗药物。
