Department of Otorhinolaryngology, Kyung Hee University School of Medicine, Seoul, Korea.
Department of Otorhinolaryngology Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
Clin Exp Otorhinolaryngol. 2014 Jun;7(2):79-86. doi: 10.3342/ceo.2014.7.2.79. Epub 2014 May 21.
Otitis media (OM) is an infectious disease that affects all age brackets. Aural discharge is a typical symptom, occurring in all subtypes of OM. We have compared the identity and antibiotic sensitivity of bacteria isolated from aural discharges of adults and children with various types of OM, including acute OM (AOM), OM with effusion (OME), chronic OM (COM), and cholesteatomatous OM (CSOM).
The study involved 2,833 patients who visited five tertiary hospitals between January 2001 and December 2010 and were diagnosed with AOM, OME, COM, or CSOM. The patients were divided into a pediatric group and an adult group, and the distribution of cultured bacteria and their antibiotic sensitivity were compared in the two groups.
Bacterial detection rates were higher in adults than in children with OME and COM (P=0.000 each). The majority of the bacteria cultured from patients with AOM and OME bacteria were methicillin-susceptible Staphylococcus aureus (MSSA) and Streptococcus pneumoniae. Bacteria cultured from children were more susceptible to antibiotics (P=0.002) and had higher antibiotic sensitivity (P=0.001) than were bacteria cultured from adults. The majority of bacteria culture from patients with COM and CSOM were MSSA and pathogenic Pseudomonas aeruginosa. The frequency of methicillin-resistant Staphylococcus aureus was significantly higher in adults than in children, and more strains of bacteria isolated from adults were sensitive to the antibiotics septrin, vancomycin, and teicoplanin.
Bacteria cultured from children were more susceptible to antibiotics and had higher antibiotic sensitivity than did bacteria cultured from adults.
中耳炎（OM）是一种影响所有年龄段的传染病。耳溢液是一种典型症状，发生在所有类型的 OM 中。我们比较了成人和儿童不同类型 OM（包括急性 OM（AOM）、伴渗出性 OM（OME）、慢性 OM（COM）和胆脂瘤性 OM（CSOM））中耳分泌物中分离的细菌的特征和抗生素敏感性。
本研究纳入了 2001 年 1 月至 2010 年 12 月期间在五所三级医院就诊并被诊断为 AOM、OME、COM 或 CSOM 的 2833 名患者。将患者分为儿科组和成年组，比较两组患者培养的细菌分布及其抗生素敏感性。
OME 和 COM 患者中，成人的细菌检出率高于儿童（P 值均为 0.000）。AOM 和 OME 患者培养的大多数细菌为耐甲氧西林金黄色葡萄球菌（MSSA）和肺炎链球菌。儿童培养的细菌对药物更敏感（P=0.002），抗生素敏感性更高（P=0.001）。COM 和 CSOM 患者培养的大多数细菌为 MSSA 和致病性铜绿假单胞菌。成人耐甲氧西林金黄色葡萄球菌的发生率明显高于儿童，而且更多的成人分离菌株对药物复方新诺明、万古霉素和替考拉宁敏感。
与成人培养的细菌相比，儿童培养的细菌对药物更敏感，抗生素敏感性更高。
