Li Jing, Liu Mengchun, Zong Jinbao, Tan Ping, Wang Jingli, Wang Xunfeng, Ye Yuanhua, Liu Shiguo, Liu Xuemei
1] Department of clinical laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China [2].
1] Nephrology department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, 266003, China [2].
Sci Rep. 2014 Jun 11;4:5250. doi: 10.1038/srep05250.
Preeclampsia (PE) is an excessive systemic inflammation response with dysfunction of endothelial. Our study was to investigate the association between genetic variations in IL-1 and the susceptibility to PE in Chinese Han population. 402 PE patients and 554 normal pregnant women of third trimester were enrolled. The polymorphisms of rs315952 in IL1RN and rs17561 in IL1A were genotyped by TaqMan allelic discrimination real-time PCR. Obviously statistic difference of the genotypic frequencies were found in both of IL1RN rs315952 and IL1A rs17561 between cases and controls (for rs315952, P = 0.001; for rs17561, P = 0.021.). For rs315952, the C allele was associated with development of PE (P = 0.003, OR = 1.319, 95%CI 1.099-1.583). Patients with CC or CT genotype were less likely to develop severe PE than patients carrying TT genotype(P < 0.001, OR = 0.24, 95%CI 0.15-0.40). For rs17561, the C allele was the risk factor for predisposition to PE (P = 0.012, OR = 1.496, 95%CI 1.089-2.055). Our results suggest IL1RN and IL1A may involve in the development of PE in Chinese Han population.
子痫前期（PE）是一种伴有内皮功能障碍的过度全身性炎症反应。我们的研究旨在调查白细胞介素-1（IL-1）基因变异与中国汉族人群患PE易感性之间的关联。纳入了402例PE患者和554例孕晚期正常孕妇。采用TaqMan等位基因鉴别实时荧光定量PCR技术对IL1RN基因的rs315952位点和IL1A基因的rs17561位点进行基因分型。病例组和对照组在IL1RN基因的rs315952位点和IL1A基因的rs17561位点的基因型频率均存在明显的统计学差异（rs315952位点，P = 0.001；rs17561位点，P = 0.021）。对于rs315952位点，C等位基因与PE的发生相关（P = 0.003，比值比[OR]=1.319，95%置信区间[CI]为1.099 - 1.583）。CC或CT基因型的患者发生重度PE的可能性低于携带TT基因型的患者（P < 0.001，OR = 0.24，95%CI为0.15 - 0.40）。对于rs17561位点，C等位基因是PE易感性的危险因素（P = 0.012，OR = 1.496，95%CI为1.089 - 2.055）。我们的结果表明，IL1RN和IL1A可能参与了中国汉族人群PE的发生发展。
