Tekce H, Tekce B K, Aktas G, Alcelik A, Sengul E
Faculty of Medicine, Department of Internal Medicine, Abant Izzet Baysal University, Bolu, Turkey.
Faculty of Medicine, Department of Medical Biochemistry, Abant Izzet Baysal University, Bolu, Turkey.
Exp Clin Endocrinol Diabetes. 2014 Sep;122(8):451-6. doi: 10.1055/s-0034-1375674. Epub 2014 Jun 11.
Omentin-1, a novel adipokine identified in visceral adipose tissue, is negatively correlated with different conditions such as diabetes, obesity and inflammation. However, changes in serum Omentin levels associated with the degree of the renal dysfunction and metabolic risk factors in CKD patients has not yet been revealed. In the present study, we aimed to investigate the level of Omentin-1 and related para-meters in diabetic and non-diabetic CKD patients.
64 (30 diabetic, 34 non-diabetic) CKD patients and 27 healthy control subjects enrolled in this cross-sectional study. Anthropometric and laboratory assessment performed and malnutrition and inflammation components evaluated. Serum concentrations of Omentin-1 and insulin were measured by using ELISA.
Serum Omentin-1 levels in CKD patients were significantly lower compared to the healthy controls. Further analyze revealed that decreased omentin in CKD patients was due to the reduced omentin levels in the diabetic subgroup. An increase in inflammation and malnutrition components was correlated with a decrease in the serum level of Omentin. Omentin levels were lower in stage 2 and 3 CKD but not stage 4 CKD patients compared to control.
The results of the present study suggest that diabetes mellitus and inflammation should be associated with lower omentin levels in CKD population; however, this reduction resolves due to the failure of degradation and excretion of omentin when creatinine clearance falls below 30 ml/min (stage 4 CKD).
网膜素-1是在内脏脂肪组织中发现的一种新型脂肪因子，与糖尿病、肥胖和炎症等不同病症呈负相关。然而，尚未揭示慢性肾脏病（CKD）患者血清网膜素水平与肾功能不全程度及代谢风险因素之间的关系。在本研究中，我们旨在调查糖尿病和非糖尿病CKD患者的网膜素-1水平及相关参数。
64例（30例糖尿病患者，34例非糖尿病患者）CKD患者和27名健康对照者纳入本横断面研究。进行人体测量和实验室评估，并评估营养不良和炎症指标。采用酶联免疫吸附测定法（ELISA）检测血清网膜素-1和胰岛素浓度。
与健康对照者相比，CKD患者的血清网膜素-1水平显著降低。进一步分析显示，CKD患者网膜素水平降低是由于糖尿病亚组中网膜素水平降低所致。炎症和营养不良指标的增加与血清网膜素水平的降低相关。与对照组相比，2期和3期CKD患者的网膜素水平较低，但4期CKD患者并非如此。
本研究结果表明，糖尿病和炎症与CKD人群中较低的网膜素水平相关；然而，当肌酐清除率降至30 ml/min以下（4期CKD）时，由于网膜素降解和排泄功能衰竭，这种降低现象消失。
