Cayir Yasemin, Cayir Atilla, Turan Mehmet Ibrahim, Kurt Nezahat, Kara Mustafa, Laloglu Esra, Ciftel Murat, Yildirim Abdulkadir
Faculty of Medicine, Department of Family Medicine, Ataturk University, Erzurum, Turkey.
Biol Trace Elem Res. 2014 Aug;160(2):155-60. doi: 10.1007/s12011-014-0038-0. Epub 2014 Jun 13.
Obesity is known to lead to complications involving several systems. The basic mechanism in obesity-related complications is chronic inflammation and increased oxidative stress. Trace element levels in obese children may vary due to poor nutritional habits. The purpose of this study was to investigate the relation between serum paraoxonase (PON1) and arylesterase (ARE) levels, markers of the oxidant-antioxidant balance in the body, and serum zinc (Zn), copper (Cu), manganese (Mn), and selenium (Se) concentrations in obese children. Fifty-seven overweight patients aged 6-17 and 48 age- and sex-matched healthy children were included in the study. Serum PON1 and ARE activity levels were measured, together with Cu, Zn, Mn, Se, total cholesterol, triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, glucose, aspartate amino transferase, and alanine amino transferase levels. PON1 and ARE activity levels were significantly lower in obese patients compared to those in healthy individuals (P < 0.05). Various changes were determined in Cu, Zn, Mn, and Se levels between the study and control groups (P < 0.05). In terms of the relation between trace elements and PON1 and ARE levels, a significant positive correlation was determined between serum Se and PON1 levels in the study group (P < 0.05, r = 0.31). No significant correlation was determined between other trace element levels and PON1 and ARE levels (P > 0.05). In conclusion, the detection in our study of a positive correlation between Se and PON1 levels in obese children may be significant in terms of showing a relation between Se and antioxidant systems in obese children.
众所周知，肥胖会导致涉及多个系统的并发症。肥胖相关并发症的基本机制是慢性炎症和氧化应激增加。肥胖儿童的微量元素水平可能因不良饮食习惯而有所不同。本研究的目的是调查肥胖儿童血清对氧磷酶（PON1）和芳基酯酶（ARE）水平（体内氧化-抗氧化平衡的标志物）与血清锌（Zn）、铜（Cu）、锰（Mn）和硒（Se）浓度之间的关系。本研究纳入了57名6-17岁的超重患者和48名年龄及性别匹配的健康儿童。测量了血清PON1和ARE活性水平，以及Cu、Zn、Mn、Se、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、极低密度脂蛋白、葡萄糖、天冬氨酸转氨酶和丙氨酸转氨酶水平。与健康个体相比，肥胖患者的PON1和ARE活性水平显著降低（P < 0.05）。研究组和对照组之间的Cu、Zn、Mn和Se水平存在各种变化（P < 0.05）。就微量元素与PON1和ARE水平之间的关系而言，研究组中血清Se与PON1水平之间存在显著正相关（P < 0.05，r = 0.31）。其他微量元素水平与PON1和ARE水平之间未发现显著相关性（P > 0.05）。总之，我们的研究发现肥胖儿童中Se与PON1水平之间存在正相关，这对于揭示肥胖儿童中Se与抗氧化系统之间的关系可能具有重要意义。
