Doufekas Konstantinos, Olaitan Adeola
Department of Gynaecological Oncology, University College London Hospitals, London, UK.
Int J Womens Health. 2014 May 23;6:537-45. doi: 10.2147/IJWH.S40894. eCollection 2014.
Epithelial ovarian cancer is the fifth commonest cancer among women and the leading cause of gynecological cancer death in the UK. Most women present with advanced disease, mainly because the nonspecific nature of the symptoms lead to diagnostic delays. Recent data have shown a fall in ovarian cancer mortality rates in the UK, but rates are still higher when compared to other European countries or the USA. In addition, surgeons in the UK achieve on average lower optimal surgical cytoreduction rates in patients with advanced ovarian cancer. Despite a wealth of information on epidemiological risk factors, the pathogenesis of epithelial ovarian cancer remains largely unknown. This review presents the most recent data on incidence, mortality, and survival for epithelial ovarian cancer in the UK. Time trends, trends by age, international comparisons, and regional variation in incidence, survival, and mortality are presented within the context of a major reorganization of cancer services that took place in the UK over 10 years ago. Centralization of cancer services has meant that women with ovarian cancer receive treatment in specialist Cancer Centers.
上皮性卵巢癌是女性中第五大常见癌症，也是英国妇科癌症死亡的主要原因。大多数女性就诊时已处于晚期疾病阶段，主要是因为症状的非特异性导致诊断延迟。最近的数据显示，英国卵巢癌死亡率有所下降，但与其他欧洲国家或美国相比，死亡率仍然较高。此外，英国的外科医生对晚期卵巢癌患者进行最佳手术细胞减灭术的平均比率较低。尽管有大量关于流行病学危险因素的信息，但上皮性卵巢癌的发病机制在很大程度上仍然未知。本综述介绍了英国上皮性卵巢癌发病率、死亡率和生存率的最新数据。在10多年前英国癌症服务进行重大重组的背景下，呈现了时间趋势、年龄趋势、国际比较以及发病率、生存率和死亡率的地区差异。癌症服务的集中化意味着卵巢癌女性患者在专科癌症中心接受治疗。
