Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of São Paulo (FOB-USP), Alameda Octávio Pinheiro Brisola, 9-75, Vila Universitária, Bauru, SP, 17012-901, Brazil.
Department of Public Health, Bauru School of Dentistry, University of São Paulo, Alameda Octávio Pinheiro Brisola, 9-75, Vila Universitária, Bauru, SP, 17012-901, Brazil.
Odontology. 2021 Jul;109(3):561-567. doi: 10.1007/s10266-020-00576-y. Epub 2021 Jan 2.
The objectives are to identify volatile sulphur compounds (VSCs) in individuals with Chronic Kidney Disease (CKD) and to relate quality of life and oral health. A case-control study with 32 individuals with CKD in haemodialysis in the study group (SG) and 32 healthy individuals in the control group (CG) was performed. The VSCs were identified by gas chromatograph before (BC) and after cysteine (AC) mouthwash and an organoleptic test. For oral health assessment, oral health index was used. For quality of life, the Oral Health Impact Profile (OHIP-14) and Medical Outcomes Study 36-Item Short Form Health Survery (SF-36) were used. The hydrogen sulphide AC, methyl mercaptan AC, tongue coating, dry mouth, plaque index, and DMFT were significantly higher in the SG. VSCs did not negatively affected the impact of oral health on the quality of life in the SG but did in the CG. As for the impact of general health on quality of life, methyl mercaptan BC and AC worsened overall health in vitality and mental health, respectively. Individuals with CKD have more halitosis than healthy individuals, and it is more related to methyl mercaptan. The halitosis worsened the general quality of life of individuals with CKD. The diagnosis and identification of the origin of halitosis is important to prevent one more factor that it worsened the global quality of life of patients with CKD.
目的是鉴定慢性肾脏病（CKD）患者中的挥发性硫化合物（VSCs），并探讨其与生活质量和口腔健康的关系。本研究采用病例对照设计，纳入 32 例血液透析的 CKD 患者作为病例组（SG），32 例健康者作为对照组（CG）。使用气相色谱仪检测两组受试者使用半胱氨酸漱口前后的 VSCs，并进行嗅觉测试。采用口腔健康指数（OHI-S）评估口腔健康状况，使用口腔健康影响简表（OHIP-14）和健康调查简表 36 项（SF-36）评估生活质量。结果显示，SG 组的硫化氢 AC、甲硫醇 AC、舌苔、口干、菌斑指数和 DMFT 显著高于 CG 组。VSCs 对 SG 组口腔健康对生活质量的影响无负面影响，但对 CG 组有负面影响。至于一般健康对生活质量的影响，BC 和 AC 的甲硫醇分别使活力和心理健康的总体健康状况恶化。与健康个体相比，CKD 个体的口臭更严重，且与甲硫醇的相关性更强。口臭使 CKD 个体的一般生活质量恶化。因此，对口臭的诊断和鉴定非常重要，以防止其成为进一步恶化 CKD 患者整体生活质量的因素之一。
