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Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.长期拮抗 κ 阿片受体可预防海洛因摄入的升级和增强动机。
J Neurosci. 2013 Dec 4;33(49):19384-92. doi: 10.1523/JNEUROSCI.1979-13.2013.
2
Gabapentin treatment for alcohol dependence: a randomized clinical trial.加巴喷丁治疗酒精依赖：一项随机临床试验。
JAMA Intern Med. 2014 Jan;174(1):70-7. doi: 10.1001/jamainternmed.2013.11950.
3
Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala.κ 阿片受体激活可减少大鼠杏仁中央核的抑制性传递，并拮抗酒精的作用。
Neuropharmacology. 2014 Feb;77:294-302. doi: 10.1016/j.neuropharm.2013.10.005. Epub 2013 Oct 21.
4
Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats.长期接触尼古丁会导致大鼠出现依赖促肾上腺皮质激素释放因子1（CRF1）受体的焦虑样行为增加和痛觉过敏。
Addict Biol. 2015 Jan;20(1):56-68. doi: 10.1111/adb.12077. Epub 2013 Jul 22.
5
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake.伏隔核去极化激活型 NMDAR 皮层激活介导了抵抗性酒精摄入。
Nat Neurosci. 2013 Aug;16(8):1094-100. doi: 10.1038/nn.3445. Epub 2013 Jun 30.
6
Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction.阿片 κ 受体介导的可卡因成瘾中海马中央杏仁核γ-氨基丁酸能传递失调。
Biol Psychiatry. 2013 Oct 1;74(7):520-8. doi: 10.1016/j.biopsych.2013.04.028. Epub 2013 Jun 14.
7
Addiction as a stress surfeit disorder.成瘾作为一种应激过度障碍。
Neuropharmacology. 2014 Jan;76 Pt B(0 0):370-82. doi: 10.1016/j.neuropharm.2013.05.024. Epub 2013 Jun 6.
8
Negative reinforcement in drug addiction: the darkness within.药物成瘾中的负性强化：内心的黑暗。
Curr Opin Neurobiol. 2013 Aug;23(4):559-63. doi: 10.1016/j.conb.2013.03.011. Epub 2013 Apr 27.
9
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.内侧眶额皮质 mGluR2 不足的挽救恢复了酒精依赖者对觅药行为的控制。
J Neurosci. 2013 Feb 13;33(7):2794-806. doi: 10.1523/JNEUROSCI.4062-12.2013.
10
Extended heroin access increases heroin choices over a potent nondrug alternative.延长海洛因获取途径会增加人们对强力非毒品替代品的海洛因选择。
Neuropsychopharmacology. 2013 Jun;38(7):1209-20. doi: 10.1038/npp.2013.17. Epub 2013 Jan 15.

Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction.

作者信息

George Olivier, Koob George F, Vendruscolo Leandro F

机构信息

Committee on the Neurobiology of Addictive Disorders, Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2400, La Jolla, CA, 92037, USA,

出版信息

Psychopharmacology (Berl). 2014 Oct;231(19):3911-7. doi: 10.1007/s00213-014-3623-1. Epub 2014 Jun 13.

DOI:10.1007/s00213-014-3623-1
PMID:24923982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8278497/
Abstract
摘要