Stukalov S V
Biull Eksp Biol Med. 1989 Jan;107(1):85-7.
Thiophosphamide (T) was i.v. administered into New Zealand rabbit (4 mg/kg). The rate of SCE in blood lymphocytes was increased up to 21st day after T administration. There are two phases in dynamics curve of SCE--a rapid phase and a slow one. The rapid decrease of SCE's rate depends on cell mortality. The slow decrease of SCE rate is connected with reparation of chromosome damages and selection of cells in lymphopoietic tissue. It was demonstrated that the special class of cells with intermediate number of SCE exists in blood after T administration.
将硫代磷酰胺（T）静脉注射给新西兰兔（4毫克/千克）。给药后直至第21天，血液淋巴细胞中的姐妹染色单体交换（SCE）率升高。SCE动态曲线有两个阶段——快速阶段和缓慢阶段。SCE率的快速下降取决于细胞死亡率。SCE率的缓慢下降与染色体损伤的修复以及淋巴造血组织中细胞的选择有关。结果表明，给药后血液中存在一类SCE数量中等的特殊细胞。
