Zao Jamie, Koren Gideon, Bozzo Pina
Can Fam Physician. 2014 Jun;60(6):539-40.
My patient has a urinary tract infection and is currently breastfeeding. Her son is only 3 weeks old. Is nitrofurantoin a safe antibiotic for treatment?
The use of nitrofurantoin in breastfeeding mothers is generally safe, as only small amounts transfer into the breast milk. Despite the lack of documented reports, there is a risk of hemolytic anemia in all newborns exposed to nitrofurantoin owing to their glutathione instability, especially in infants with glucose-6-phosphate dehydrogenase deficiency. Although some suggest that nitrofurantoin be avoided in infants younger than 1 month, studies have noted that glutathione stability might be established by the eighth day of life. In infants younger than 1 month, an alternative antibiotic might be preferred; however, if an alternative were not available, the use of nitrofurantoin would not be a reason to avoid breastfeeding. In any such case the suckling infant should be monitored by his or her physician.
我的患者患有尿路感染，目前正在哺乳期。她的儿子只有3周大。呋喃妥因是一种治疗的安全抗生素吗？
哺乳期母亲使用呋喃妥因通常是安全的，因为只有少量药物会进入母乳。尽管缺乏文献报道，但由于所有接触呋喃妥因的新生儿谷胱甘肽不稳定，尤其是葡萄糖-6-磷酸脱氢酶缺乏的婴儿，存在溶血性贫血的风险。虽然有人建议1个月以下的婴儿避免使用呋喃妥因，但研究指出，谷胱甘肽稳定性可能在出生后第八天建立。对于1个月以下的婴儿，可能首选其他抗生素；然而，如果没有其他选择，使用呋喃妥因并不是避免母乳喂养的理由。在任何这种情况下，哺乳婴儿应由其医生进行监测。
