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在眼形区域上具有蒸发、湿润和时间相关通量边界条件的泪膜动力学。

Tear film dynamics with evaporation, wetting, and time-dependent flux boundary condition on an eye-shaped domain.

作者信息

Li Longfei, Braun R J, Maki K L, Henshaw W D, King-Smith P E

机构信息

Department of Mathematical Sciences, University of Delaware, Newark, Delaware 19716, USA.

School of Mathematical Sciences, Rochester Institute of Technology, Rochester, New York 14623, USA.

出版信息

Phys Fluids (1994). 2014 May;26(5):052101. doi: 10.1063/1.4871714. Epub 2014 May 6.

DOI:10.1063/1.4871714
PMID:24926191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4032440/
Abstract

We study tear film dynamics with evaporation on a wettable eye-shaped ocular surface using a lubrication model. The mathematical model has a time-dependent flux boundary condition that models the cycles of tear fluid supply and drainage; it mimics blinks on a stationary eye-shaped domain. We generate computational grids and solve the nonlinear governing equations using the OVERTURE computational framework. experimental results using fluorescent imaging are used to visualize the influx and redistribution of tears for an open eye. Results from the numerical simulations are compared with the experiment. The model captures the flow around the meniscus and other dynamic features of human tear film observed .

摘要

我们使用润滑模型研究了在可湿润的眼形眼表上有蒸发情况下的泪膜动力学。该数学模型具有一个随时间变化的通量边界条件,用于模拟泪液供应和排出的循环;它在一个固定的眼形区域上模拟眨眼。我们生成计算网格,并使用OVERTURE计算框架求解非线性控制方程。利用荧光成像的实验结果来可视化睁眼时泪液的流入和重新分布。将数值模拟结果与实验进行比较。该模型捕捉到了观察到的围绕泪液弯月面的流动以及人泪膜的其他动态特征。

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本文引用的文献

1
A model for tear film thinning with osmolarity and fluorescein.泪膜变薄的渗透压和荧光模型。
Invest Ophthalmol Vis Sci. 2014 Feb 26;55(2):1133-42. doi: 10.1167/iovs.13-12773.
2
Tear film images and breakup analyzed using fluorescent quenching.使用荧光猝灭分析泪膜图像和破裂。
Invest Ophthalmol Vis Sci. 2013 Sep 5;54(9):6003-11. doi: 10.1167/iovs.13-12628.
3
The use of fluorescent quenching in studying the contribution of evaporation to tear thinning.利用荧光猝灭研究蒸发对泪膜变薄的贡献。
Invest Ophthalmol Vis Sci. 2012 Aug 20;53(9):5426-32. doi: 10.1167/iovs.12-10033.
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Coupling fluid and solute dynamics within the ocular surface tear film: a modelling study of black line osmolarity.眼表面泪膜中液体和溶质动力学的耦合:黑线渗透压的建模研究。
Bull Math Biol. 2012 Sep;74(9):2062-93. doi: 10.1007/s11538-012-9746-9. Epub 2012 Jul 6.
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High resolution microscopy of the lipid layer of the tear film.泪膜脂质层的高分辨率显微镜检查。
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6
Tear osmolarity in the diagnosis and management of dry eye disease.泪液渗透压在干眼疾病的诊断和治疗中的作用。
Am J Ophthalmol. 2011 May;151(5):792-798.e1. doi: 10.1016/j.ajo.2010.10.032. Epub 2011 Feb 18.
7
Evidence for the major contribution of evaporation to tear film thinning between blinks.证据表明,眨眼间泪膜变薄的主要原因是蒸发。
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6294-7. doi: 10.1167/iovs.09-4772. Epub 2010 Aug 4.
8
Membrane-tethered mucins have multiple functions on the ocular surface.膜结合黏蛋白在眼表面具有多种功能。
Exp Eye Res. 2010 Jun;90(6):655-63. doi: 10.1016/j.exer.2010.02.014. Epub 2010 Mar 16.
9
Tear film dynamics on an eye-shaped domain I: pressure boundary conditions.眼形区域上的泪膜动力学 I:压力边界条件
Math Med Biol. 2010 Sep;27(3):227-54. doi: 10.1093/imammb/dqp023. Epub 2010 Jan 11.
10
Inputs and outputs of the lacrimal system: review of production and evaporative loss.泪液系统的输入和输出:生产和蒸发损失的综述。
Ocul Surf. 2009 Oct;7(4):186-98. doi: 10.1016/s1542-0124(12)70186-6.