Berger P K, Pollock N K, Laing E M, Warden S J, Hill Gallant K M, Hausman D B, Tripp R A, McCabe L D, McCabe G P, Weaver C M, Peacock M, Lewis R D
Department of Foods and Nutrition (P.K.B., E.M.L., D.B.H., R.D.L.), The University of Georgia, Athens, Georgia 30602; Department of Pediatrics (N.K.P.), Georgia Regents University, Augusta, Georgia 30912; Department of Physical Therapy (S.J.W.), Indiana University School of Health and Rehabilitation Sciences, and Department of Medicine (K.M.H.G., M.P.), Indiana University School of Medicine, Indianapolis, Indiana 46202; Departments of Nutrition Science (K.M.H.G., L.D.M., C.M.W.) and Statistics (G.P.M.), Purdue University, West Lafayette, Indiana 47907; and Department of Infectious Diseases (R.A.T.), The University of Georgia, Athens, Georgia 30602.
J Clin Endocrinol Metab. 2014 Sep;99(9):3240-6. doi: 10.1210/jc.2014-1780. Epub 2014 Jun 13.
Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal.
Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9-13 years (50% female, 49% black).
Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-α, IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry.
The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-α and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P = .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-α, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2-4.0], 2.4 (95% CI 1.4-4.0), and 1.8 (95% CI 1.0-3.3), respectively, for those in the highest TNF-α, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05).
In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.
尽管动物研究表明腺病毒36（Ad36）感染与肥胖和全身炎症有关，但人类相关数据较少且不明确。
在291名9至13岁儿童（50%为女性，49%为黑人）中确定Ad36感染与全身肥胖及炎症相关标志物之间的关联。
检测空腹血样中Ad36特异性抗体以及肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、血管内皮生长因子（VEGF）和单核细胞趋化蛋白-1（MCP-1）的存在情况。通过双能X线吸收法测量脂肪量和去脂软组织量。
Ad36血清阳性[Ad36(+)]的总体患病率为42%。与各自的中间和最低三分位数相比，TNF-α和IL-6最高三分位数中的Ad36(+)儿童百分比更高（均P < 0.03）。与第1和第2三分位数相比，VEGF最高三分位数中的Ad36(+)儿童患病率也有升高趋势（P = 0.05）。在对年龄、种族、性别和去脂软组织量进行校正的多项逻辑回归分析中，结果显示，与TNF-α、IL-6和VEGF水平最低（第1三分位数）的儿童相比，TNF-α、IL-6和VEGF水平最高（第3三分位数）的儿童中Ad36(+)的校正比值比分别为2.2[95%置信区间（CI）1.2 - 4.0]、2.4（95% CI 1.4 - 4.0）和1.8（95% CI 1.0 - 3.3）。未观察到Ad36(+)与更高的脂肪量或MCP-1水平之间存在关联（所有P > 0.05）。
在儿童中，我们的数据表明Ad36(+)可能与炎症相关生物标志物有关，但与更高的脂肪量无关。
