Gao Fei, Feng Xiaohua, Zheng Yuanjin, Ohl Claus-Dieter
Nanyang Technological University, School of Electrical and Electronic Engineering, 50 Nanyang Avenue, 639798 Singapore.
Nanyang Technological University, School of Physical and Mathematical Sciences, 50 Nanyang Avenue, 639798 Singapore.
J Biomed Opt. 2014 Jun;19(6):067006. doi: 10.1117/1.JBO.19.6.067006.
By "listening to photons," photoacoustics allows the probing of chromosomes in depth beyond the optical diffusion limit. Here we report the photoacoustic resonance effect induced by multiburst modulated laser illumination, which is theoretically modeled as a damped mass-string oscillator and a resistor-inductor-capacitor (RLC) circuit. Through sweeping the frequency of multiburst modulated laser, the photoacoustic resonance effect is observed experimentally on phantoms and porcine tissues. Experimental results demonstrate different spectra for each phantom and tissue sample to show significant potential for spectroscopic analysis, fusing optical absorption and mechanical vibration properties. Unique RLC circuit parameters are extracted to quantitatively characterize phantom and biological tissues.
通过“倾听光子”，光声技术能够深入探测超出光学扩散极限的染色体。在此，我们报告了由多脉冲调制激光照射引起的光声共振效应，其在理论上被建模为一个阻尼质量 - 弦振荡器和一个电阻 - 电感 - 电容（RLC）电路。通过扫描多脉冲调制激光的频率，在体模和猪组织上实验观察到了光声共振效应。实验结果表明，每个体模和组织样本都有不同的光谱，显示出在融合光吸收和机械振动特性的光谱分析方面具有巨大潜力。提取了独特的RLC电路参数以定量表征体模和生物组织。
