Key Laboratory for Ecological Environment in Coastal Areas (SOA), National Marine Environmental Monitoring Center, Dalian, China; Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
Key Laboratory for Ecological Environment in Coastal Areas (SOA), National Marine Environmental Monitoring Center, Dalian, China; Dalian Polytechnic University, Dalian, China.
Mar Pollut Bull. 2014 Jul 15;84(1-2):70-5. doi: 10.1016/j.marpolbul.2014.05.039. Epub 2014 Jun 11.
Antibiotic resistance gene (ARG) residues and the mode of transmission in marine environments remain unclear. The sulfonamide (SAs) concentrations, different genes and total bacterial abundance in seawater and sediment of the Northern Yellow Sea were analyzed. Results showed the genes sul I and sul II were present at relatively high concentrations in all samples, whereas the gene sul III was detected fewer. The ARGs concentrations in the sediment were 10(3) times higher than those in water, which indicated sediment was essential ARG reservoir. Statistical analysis revealed the total antibiotic concentration was positively correlated with the relative abundance of the gene sul I and sul II. The relative abundances of the gene sul I and the gene sul II were also correlated positively with those of the gene int1. This correlation demonstrated that SAs exerted selective pressure on these ARGs, whereas the gene int1 could be implicated in the propagation of the genes sul I and sul II in marine environments.
海洋环境中抗生素耐药基因 (ARG) 残留及其传播方式仍不清楚。本研究分析了黄海北部海水和沉积物中的磺胺类 (SAs) 浓度、不同基因和总细菌丰度。结果表明，所有样品中均存在相对较高浓度的 sul I 和 sul II 基因，而 sul III 基因的检出率较低。沉积物中 ARG 浓度是水体中的 10(3) 倍，表明沉积物是 ARG 的重要储存库。统计分析显示，抗生素总量与基因 sul I 和 sul II 的相对丰度呈正相关。基因 sul I 和 sul II 的相对丰度与基因 int1 的相对丰度也呈正相关。这种相关性表明，SAs 对这些 ARGs 施加了选择性压力，而基因 int1 可能参与了海洋环境中基因 sul I 和 sul II 的传播。
