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本文引用的文献

1
Waist:height ratio: a superior index in estimating cardiovascular risks in Turkish adults.腰高比：评估土耳其成年人心血管风险的一项优越指标。
Public Health Nutr. 2014 Oct;17(10):2246-52. doi: 10.1017/S136898001300267X. Epub 2013 Oct 8.
2
Cerebrospinal fluid inflammatory markers in Parkinson's disease--associations with depression, fatigue, and cognitive impairment.帕金森病患者脑脊液中的炎症标志物与抑郁、疲劳和认知障碍的相关性。
Brain Behav Immun. 2013 Oct;33:183-9. doi: 10.1016/j.bbi.2013.07.007. Epub 2013 Jul 31.
3
Obesity increases cerebrocortical reactive oxygen species and impairs brain function.肥胖会增加大脑皮质的活性氧物种，并损害大脑功能。
Free Radic Biol Med. 2013 Mar;56:226-33. doi: 10.1016/j.freeradbiomed.2012.08.577. Epub 2012 Oct 29.
4
Midlife rheumatoid arthritis increases the risk of cognitive impairment two decades later: a population-based study.中年类风湿性关节炎会增加 20 年后认知障碍的风险：一项基于人群的研究。
J Alzheimers Dis. 2012;31(3):669-76. doi: 10.3233/JAD-2012-111736.
5
Serum leptin and cognitive function in people with type 2 diabetes.血清瘦素与 2 型糖尿病患者的认知功能。
Neurobiol Aging. 2012 Dec;33(12):2938-2941.e2. doi: 10.1016/j.neurobiolaging.2012.02.026. Epub 2012 Apr 3.
6
Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?轻度认知障碍和痴呆症中的饮酒行为：有害还是神经保护？
Int J Geriatr Psychiatry. 2012 Dec;27(12):1218-38. doi: 10.1002/gps.3772. Epub 2012 Mar 7.
7
Elevated levels of high-sensitivity C-reactive protein are associated with mild cognitive impairment and its subtypes: results of a population-based case-control study.高水平的高敏 C 反应蛋白与轻度认知障碍及其亚型相关：一项基于人群的病例对照研究结果。
J Alzheimers Dis. 2012;28(3):503-14. doi: 10.3233/JAD-2011-111352.
8
C-reactive protein is related to memory and medial temporal brain volume in older adults.C-反应蛋白与老年人的记忆和内侧颞叶脑容量有关。
Brain Behav Immun. 2012 Jan;26(1):103-8. doi: 10.1016/j.bbi.2011.07.240. Epub 2011 Aug 6.
9
C-reactive protein expression in a rodent model of chronic cerebral hypoperfusion.慢性脑低灌注啮齿动物模型中的 C 反应蛋白表达。
Brain Res. 2011 Sep 26;1414:85-93. doi: 10.1016/j.brainres.2011.07.047. Epub 2011 Jul 29.
10
Cognitive impairment using education-based cutoff points for CMMSE scores in elderly Chinese people of agricultural and rural Shanghai China.使用基于教育的 CMMSE 评分界值对中国上海农村老年人群认知障碍的评估。
Acta Neurol Scand. 2011 Dec;124(6):361-7. doi: 10.1111/j.1600-0404.2010.01484.x. Epub 2011 Feb 9.

中国上海郊区老年人的认知障碍：C反应蛋白的关联及其与其他相关因素的相互作用

Cognitive impairment among elderly individuals in Shanghai suburb, China: association of C-reactive protein and its interactions with other relevant factors.

作者信息

Chen Jin-Mei, Cui Guo-Hong, Jiang Guo-Xin, Xu Rui-Fang, Tang Hui-Dong, Wang Gang, Chen Sheng-Di, Cheng Qi

机构信息

Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China School of Public Health, Shanghai Jiao Tong University, China.

School of Public Health, Shanghai Jiao Tong University, China Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.

出版信息

Am J Alzheimers Dis Other Demen. 2014 Dec;29(8):712-7. doi: 10.1177/1533317514534758. Epub 2014 Jun 13.

DOI:10.1177/1533317514534758
PMID:24928820
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10852731/
Abstract

OBJECTIVES

To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors.

METHODS

Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis.

RESULTS

The mean CRP in patients with cognitive impairment was higher than that in controls (P < .001). The highest quartile of CRP (>4.77 mg/L), abdomen obesity, hypertriglyceridemia, and hyperglycemia was associated with cognitive impairment. Significant interactions were found between increased CRP and hypertriglyceridemia as well as between increased CRP and hyperglycemia on cognitive impairment; and the attributable proportion due to interaction was 82% (P < .0001) and 37% (P = .007), respectively.

CONCLUSIONS

Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals.

摘要

目的

研究血清C反应蛋白（CRP）浓度与认知障碍之间的关联以及CRP与其他相关因素之间的相互作用。

方法

从上海郊区60岁及以上居民的一项基于人群的研究中选取认知障碍患者以及1至2名年龄和性别匹配的对照。采用逻辑回归分析检测血清CRP浓度及其他相关因素之间的关联。

结果

认知障碍患者的平均CRP高于对照组（P <.001）。CRP最高四分位数（>4.77 mg/L）、腹部肥胖、高甘油三酯血症和高血糖与认知障碍相关。发现CRP升高与高甘油三酯血症之间以及CRP升高与高血糖之间在认知障碍方面存在显著相互作用；相互作用导致的归因比例分别为82%（P <.0001）和37%（P =.007）。

结论

CRP升高与认知障碍相关，且在老年人中观察到CRP升高与高甘油三酯血症和高血糖在认知障碍方面存在相加效应。