中国上海郊区老年人的认知障碍：C反应蛋白的关联及其与其他相关因素的相互作用
Cognitive impairment among elderly individuals in Shanghai suburb, China: association of C-reactive protein and its interactions with other relevant factors.
作者信息
Chen Jin-Mei, Cui Guo-Hong, Jiang Guo-Xin, Xu Rui-Fang, Tang Hui-Dong, Wang Gang, Chen Sheng-Di, Cheng Qi
机构信息
Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, China School of Public Health, Shanghai Jiao Tong University, China.
School of Public Health, Shanghai Jiao Tong University, China Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden.
出版信息
Am J Alzheimers Dis Other Demen. 2014 Dec;29(8):712-7. doi: 10.1177/1533317514534758. Epub 2014 Jun 13.
OBJECTIVES
To investigate the association between serum C-reactive protein (CRP) concentration and cognitive impairment as well as interactions between CRP and other relevant factors.
METHODS
Patients with cognitive impairment and 1 to 2 age- and sex-matched controls nested from a population-based study among residents aged 60 years and older in Shanghai suburb. The associations of serum CRP concentration and other relevant factors were examined with logistic regression analysis.
RESULTS
The mean CRP in patients with cognitive impairment was higher than that in controls (P < .001). The highest quartile of CRP (>4.77 mg/L), abdomen obesity, hypertriglyceridemia, and hyperglycemia was associated with cognitive impairment. Significant interactions were found between increased CRP and hypertriglyceridemia as well as between increased CRP and hyperglycemia on cognitive impairment; and the attributable proportion due to interaction was 82% (P < .0001) and 37% (P = .007), respectively.
CONCLUSIONS
Increased CRP was associated with cognitive impairment, and additive effects of increased CRP with hypertriglyceridemia and hyperglycemia on cognitive impairment were observed among elderly individuals.
目的
研究血清C反应蛋白（CRP）浓度与认知障碍之间的关联以及CRP与其他相关因素之间的相互作用。
方法
从上海郊区60岁及以上居民的一项基于人群的研究中选取认知障碍患者以及1至2名年龄和性别匹配的对照。采用逻辑回归分析检测血清CRP浓度及其他相关因素之间的关联。
结果
认知障碍患者的平均CRP高于对照组（P <.001）。CRP最高四分位数（>4.77 mg/L）、腹部肥胖、高甘油三酯血症和高血糖与认知障碍相关。发现CRP升高与高甘油三酯血症之间以及CRP升高与高血糖之间在认知障碍方面存在显著相互作用；相互作用导致的归因比例分别为82%（P <.0001）和37%（P =.007）。
结论
CRP升高与认知障碍相关，且在老年人中观察到CRP升高与高甘油三酯血症和高血糖在认知障碍方面存在相加效应。
Zotero 插件