Bae Jisuk, Park Pil Sook, Chun Byung-Yeol, Choi Bo Youl, Kim Mi Kyung, Shin Min-Ho, Lee Young-Hoon, Shin Dong Hoon, Kim Seong-Kyu
Department of Preventive Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.
Rheumatol Int. 2015 Feb;35(2):327-36. doi: 10.1007/s00296-014-3061-8. Epub 2014 Jun 15.
Caffeine, a commonly consumed food constituent, is known to exert beneficial physiological effects in humans. There is a lack of comprehensive population data for the effects of caffeine intake on urate metabolism. Therefore, the aim of this study was to determine whether coffee, tea, and caffeine intake influences serum uric acid and the risk of hyperuricemia in the Korean Multi-Rural Communities Cohort. We enrolled 9,400 participants in this study. An assessment of various dietary intake amounts of substances such as coffee and tea was performed using a food frequency questionnaire. The content of caffeine was calculated from coffee (74 mg/cup) and tea (15 mg/cup) intake information from the past year. Multivariate logistic regression models, multiple linear regression models, and analysis of covariance were applied to identify any association of dietary intake with serum uric acid levels or the risk of hyperuricemia. No trends for coffee, tea, or caffeine intake were found according to each quintile with serum uric acid in males, although there were weak, marginally significant trends between the content of coffee and caffeine intake and serum uric acid level in females (p = 0.07 for both). Tea intake in males and caffeine intake in females were significantly different between non-hyperuricemia and hyperuricemia (p = 0.04 and p = 0.04, respectively). In addition, a significant association of serum uric acid level with tea intake in males (β = 0.0006, p = 0.02) and with tea intake and caffeine intake in females (β = 0.0003, p = 0.04 and β = 0.0006, p = 0.02, respectively) was observed. There was no effect of coffee, tea, or caffeine intake on the risk of hyperuricemia in either males or females. This study suggests that caffeine consumption might have an effect on serum uric acid in females. However, coffee, tea, and caffeine intake amounts were not associated with the risk of hyperuricemia.
咖啡因是一种常见的食物成分，已知其对人体具有有益的生理作用。目前缺乏关于咖啡因摄入对尿酸代谢影响的全面人群数据。因此，本研究的目的是在韩国多农村社区队列中确定咖啡、茶和咖啡因摄入是否会影响血清尿酸及高尿酸血症风险。我们招募了9400名参与者参与本研究。使用食物频率问卷对咖啡和茶等各种物质的不同饮食摄入量进行评估。根据过去一年的咖啡（74毫克/杯）和茶（15毫克/杯）摄入信息计算咖啡因含量。应用多变量逻辑回归模型、多元线性回归模型和协方差分析来确定饮食摄入与血清尿酸水平或高尿酸血症风险之间的任何关联。在男性中，根据血清尿酸的每个五分位数，未发现咖啡、茶或咖啡因摄入的趋势，尽管在女性中，咖啡含量与咖啡因摄入量和血清尿酸水平之间存在微弱的、边缘显著的趋势（两者p值均为0.07）。男性的茶摄入量和女性的咖啡因摄入量在非高尿酸血症和高尿酸血症之间存在显著差异（分别为p = 0.04和p = 0.04）。此外，观察到男性血清尿酸水平与茶摄入量之间存在显著关联（β = 0.0006，p = 0.02），女性血清尿酸水平与茶摄入量和咖啡因摄入量之间也存在显著关联（分别为β = 0.0003，p = 0.04和β = 0.0006，p = 0.02）。咖啡、茶或咖啡因摄入对男性或女性的高尿酸血症风险均无影响。本研究表明，咖啡因消费可能对女性血清尿酸有影响。然而，咖啡、茶和咖啡因的摄入量与高尿酸血症风险无关。
