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Hypoxic regulation of metabolism offers new opportunities for anticancer therapy.代谢的缺氧调节为抗癌治疗提供了新的机遇。
Expert Rev Anticancer Ther. 2014 Sep;14(9):979-81. doi: 10.1586/14737140.2014.930345. Epub 2014 Jun 14.
2
Hypoxia and drug resistance.缺氧与耐药性。
Cancer Metastasis Rev. 1994 Jun;13(2):139-68. doi: 10.1007/BF00689633.
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The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions.在缺氧条件下，STAT3抑制剂在人类癌细胞中的抗增殖和集落抑制活性受到损害。
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In vitro testing of chemosensitivity in physiological hypoxia.生理缺氧条件下化学敏感性的体外测试
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The Effect of Co-Delivery of Oxygen and Anticancer Drugs on the Viability of Healthy and Cancer Cells under Normoxic and Hypoxic Conditions.共递送氧和抗癌药物对常氧和缺氧条件下健康细胞和癌细胞活力的影响。
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Metabolic depression: a response of cancer cells to hypoxia?代谢抑制：癌细胞对缺氧的一种反应？
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Hypoxia and cancer cell metabolism.缺氧与肿瘤细胞代谢。
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Reprogramming of the Tumor in the Hypoxic Niche: The Emerging Concept and Associated Therapeutic Strategies.肿瘤在低氧微环境中的重编程：新兴概念及相关治疗策略。
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本文引用的文献

1
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.通过低氧诱导因子1（HIF1）和七分子同源结构域蛋白2（SIAH2）对谷氨酰胺代谢进行的低氧调节支持肿瘤生长所必需的脂质合成。
Cell Metab. 2014 Feb 4;19(2):285-92. doi: 10.1016/j.cmet.2013.11.022.
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Cancer metabolism: fatty acid oxidation in the limelight.癌症代谢：脂肪酸氧化备受关注。
Nat Rev Cancer. 2013 Apr;13(4):227-32. doi: 10.1038/nrc3483. Epub 2013 Feb 28.
3
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.PDK 对糖酵解的调节可作为造血干细胞细胞周期静止的代谢检查点。
Cell Stem Cell. 2013 Jan 3;12(1):49-61. doi: 10.1016/j.stem.2012.10.011.
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Physiological roles of mitochondrial reactive oxygen species.线粒体活性氧的生理作用。
Mol Cell. 2012 Oct 26;48(2):158-67. doi: 10.1016/j.molcel.2012.09.025.
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Cellular metabolism and disease: what do metabolic outliers teach us?细胞代谢与疾病：代谢异常者能给我们带来哪些启示？
Cell. 2012 Mar 16;148(6):1132-44. doi: 10.1016/j.cell.2012.02.032.
6
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism.线粒体丙酮酸脱氢酶激酶 1 的酪氨酸磷酸化对于癌症代谢很重要。
Mol Cell. 2011 Dec 23;44(6):864-77. doi: 10.1016/j.molcel.2011.10.015.
7
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.缺氧促进异柠檬酸脱氢酶依赖性的α-酮戊二酸的羧化作用生成柠檬酸，以支持细胞生长和存活。
Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6. doi: 10.1073/pnas.1117773108. Epub 2011 Nov 21.
8
Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?靶向代谢的抗癌药物：二氯乙酸盐是新范例吗？
Int J Cancer. 2011 Mar 1;128(5):1001-8. doi: 10.1002/ijc.25728. Epub 2010 Dec 7.
9
The molecular determinants of de novo nucleotide biosynthesis in cancer cells.癌细胞中从头核苷酸生物合成的分子决定因素。
Curr Opin Genet Dev. 2009 Feb;19(1):32-7. doi: 10.1016/j.gde.2009.01.002. Epub 2009 Feb 5.
10
Regulation of cancer cell metabolism by hypoxia-inducible factor 1.缺氧诱导因子1对癌细胞代谢的调控
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代谢的缺氧调节为抗癌治疗提供了新的机遇。

Hypoxic regulation of metabolism offers new opportunities for anticancer therapy.

作者信息

Denko Nicholas C

机构信息

Department of Radiation Oncology, Ohio State University Wexner Medical Center and OSU Comprehensive Cancer Center, Columbus, OH 43210, USA.

出版信息

Expert Rev Anticancer Ther. 2014 Sep;14(9):979-81. doi: 10.1586/14737140.2014.930345. Epub 2014 Jun 14.

DOI:10.1586/14737140.2014.930345
PMID:24930453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4289602/
Abstract

Cancer metabolism now appears to be optimized for growth of tumor cells by having an increased reliance on non-oxidative processes. However, in order to exploit these findings clinically, we must determine the specific pathways and components that cancer cells rely on, but are dispensable for normal cells. Because tumors have the added stress of hypoxia, the metabolic response to low oxygen may represent such a tumor-specific metabolic program.

摘要

癌症代谢现在似乎通过增加对非氧化过程的依赖，来优化肿瘤细胞的生长。然而，为了在临床上利用这些发现，我们必须确定癌细胞所依赖但正常细胞可以摒弃的特定途径和成分。由于肿瘤存在缺氧这一额外压力，对低氧的代谢反应可能代表这样一种肿瘤特异性代谢程序。